Chinese Journal of Tissue Engineering Research ›› 2025, Vol. 29 ›› Issue (24): 5071-5078.doi: 10.12307/2025.743

Previous Articles     Next Articles

Association of the controlling nutritional status score and systemic immune-inflammation index with postmenopausal osteoporosis

Chen Xiaoqing1, Gong Yunzhao1, 2, Chen Wei1, 2   

  1. 1Liaoning University of Traditional Chinese Medicine, Shenyang 110847, Liaoning Province, China; 2The Second Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang 110034, Liaoning Province, China
  • Received:2024-07-27 Accepted:2024-09-21 Online:2025-08-28 Published:2025-01-22
  • Contact: Chen Wei, MD, Chief physician, Master’s supervisor, Liaoning University of Traditional Chinese Medicine, Shenyang 110847, Liaoning Province, China; The Second Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang 110034, Liaoning Province, China
  • About author:Chen Xiaoqing, Master candidate, Liaoning University of Traditional Chinese Medicine, Shenyang 110847, Liaoning Province, China Gong Yunzhao, MS, Chief physician, Liaoning University of Traditional Chinese Medicine, Shenyang 110847, Liaoning Province, China; The Second Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang 110034, Liaoning Province, China Chen Xiaoqing and Gong Yunzhao contributed equally to this work.
  • Supported by:
    Basic Research Project for Higher Education Institutions of the Liaoning Provincial Department of Education, No. LJKMZ20221327 (to GYZ)

PDF

77

Abstract: BACKGROUND: The controlling nutritional status score and systemic immune-inflammation index, as tools to assess individual nutritional and inflammatory states, have been proven to be related to the risk and prognosis of various chronic diseases. However, their value in predicting postmenopausal osteoporosis has not yet been fully explored.
OBJECTIVE: To explore the applicative value of the controlling nutritional status score and systemic immune-inflammation index in predicting postmenopausal osteoporosis. 
METHODS: A retrospective analysis was conducted on the clinical data of 420 postmenopausal patients treated from January 2022 to April 2024 at the Second Affiliated Hospital of Liaoning University of Traditional Chinese Medicine and its Kangping branch. There were 205 cases in osteoporosis group and 215 in normal bone mass group. Age, years of menopause, body mass index, history of fracture, smoking history and alcohol consumption were selected as covariates. Patients were matched at a 1:1 ratio using the nearest neighbor method of propensity score matching to balance covariates between the two groups. Therefore, there were 142 patients in each of the two groups after matching. Serum levels of type I precollagen amino-terminal prepeptide, β-collagen degradation products, parathyroid hormone, and 25-hydroxyvitamin D were measured in both groups. The controlling nutritional status score and systemic immune-inflammation index were assessed by serum albumin, total cholesterol levels, neutrophil counts, lymphocyte counts, and platelet counts. The receiver operating characteristic curve was employed to analyze the optimal cutoff values and predictive effectiveness of the controlling nutritional status score and systemic immune-inflammation index. Pearson or Spearman correlations were used to analyze the relationships among the controlling nutritional status score, systemic immune-inflammation index, and bone mineral density. A multivariable logistic regression model was utilized to identify factors influencing postmenopausal osteoporosis.
RESULTS AND CONCLUSION: (1) After matching, compared with the normal bone mass group, the osteoporosis group had higher serum pre-collagen type I amino-terminal prepeptide, β-collagen degradation products, and parathyroid hormone levels (P < 0.001), lower 25-hydroxyvitamin D levels (P < 0.001), and higher malnutrition rates and immunoinflammatory indices (P < 0.001). (2) Correlation analysis showed a positive correlation between the controlling nutritional status score and systemic immune-inflammation index (r=0.462, P < 0.001), and both were negatively correlated with femoral neck bone density and lumbar spine L1-L4 bone mineral density (r=-0.322, P < 0.001; r=-0.362, P < 0.001; r=-0.322, P < 0.001; r=-0.340, P < 0.001). (3) Multivariable logistic regression analyses, before and after propensity score matching, indicated that both the controlling nutritional status score and systemic immune-inflammation index were risk factors for osteoporosis in postmenopausal patients. (4) The receiver operating characteristic curves post-matching showed that the areas under the curve for the controlling nutritional status score and systemic immune-inflammation index were 0.758 and 0.754, respectively, and the two best cutoff values were 2.50 and 694.62, respectively, suggesting that both tools perform well in predicting postmenopausal osteoporosis. To conclude, the controlling nutritional status score and systemic immune-inflammation index are effective tools for predicting postmenopausal osteoporosis, suitable for clinical use in prevention and early identification of high-risk individuals. These findings also suggest that nutritional status and inflammatory markers may be part of the pathogenesis of postmenopausal osteoporosis.

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

Key words: postmenopausal osteoporosis, propensity score matching, controlling nutritional status score, systemic inflammation index, postmenopausal women, engineered tissue construction

CLC Number: