Chinese Journal of Tissue Engineering Research ›› 2024, Vol. 28 ›› Issue (14): 2152-2158.doi: 10.12307/2024.271
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Hou Yiwen, Liu Ying, Li Zhurong, Chen Chen, Li Zhencheng, Liu Yang
Received:
2023-01-31
Accepted:
2023-03-12
Online:
2024-05-18
Published:
2023-07-28
Contact:
Liu Yang, Professor, School of Basic Medical Sciences, Shanxi University of Chinese Medicine, Jinzhong 030619, Shanxi Province, China
About author:
Hou Yiwen, Master, School of Basic Medical Sciences, Shanxi University of Chinese Medicine, Jinzhong 030619, Shanxi Province, China
Supported by:
CLC Number:
Hou Yiwen, Liu Ying, Li Zhurong, Chen Chen, Li Zhencheng, Liu Yang. Correlation analysis of circular RNAs involved in liver injury in mice with autoimmune hepatitis[J]. Chinese Journal of Tissue Engineering Research, 2024, 28(14): 2152-2158.
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2.1 CircRNAs靶基因预测和GO富集 根据P值从小到大排列,选择前30个GO条目绘制条形图,见图1。GO的富集结果显示,在P < 0.05时,差异表达的CircRNAs可以被阐释为140个GO条目,其中19项细胞组分、28项分子功能和93项生物过程;在错误发现率≤0.05的条件下,差异表达的CircRNAs可以被阐释为59个GO项。图中按P值的升序排列列出了每个类别的前10个GO项,表达上调CircRNAs的靶基因的生物过程主要为“SNARE复合装配的调节”等,分子功能主要为“金属离子结合”等,细胞组分主要为“CORVET 复合体”等;表达下调CircRNAs的靶基因的生物过程主要为“胰液分泌的负调节”等,分子功能主要为“转录激活因子活性”等,细胞组分主要为“膜外组分”等。"
进一步的分析显示,mmu-circ-0001520与谷丙转氨酶(r=0.927,P=0.007)、谷草转氨酶(r=0.904,P=0.013)、NO(r=0.880,P=0.025)存在线性正相关关系;mmu-circ-0001577与谷草转氨酶(r=0.967,P=0.001)、NO(r=0.865,P=0.026)存在线性正相关关系。mmu-circ-0001577与丙二醛(r=0.807,P=0.052),mmu-circ-0001520与谷丙转氨酶(r=0.807,P=0.052)、丙二醛(相关系数r=0.795,P=0.058)与其他指标的变化趋势也具有一致性,但没有显著的线性相关关系。"
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