Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (32): 6048-6051.doi: 10.3969/j.issn.1673-8225.2010.32.035

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Targeted therapy of surface molecules, regulatory mechanisms and microenvironment of leukemia stem cells 

Zhou Mei, Ouyang Chenxi   

  1. Department of Vascular Surgery, Union Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan  430022, Hubei Province, China
  • Online:2010-08-06 Published:2010-08-06
  • Contact: Ouyang Chenxi, Associate professor, Associate chief physician, Master’s supervisor, Department of Vascular Surgery, Union Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China ouyangchx@yahoo. Com
  • About author:Zhou Mei★, Studying for master’s degree, Department of Vascular Surgery, Union Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China zmlucia1985@yahoo.com.cn

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Abstract:

BACKGROUND: With the proposition and deep research of leukemia stem cells, it is possible to find out new ways to treat leukemia more effectively, which are targeting leukemia stem cells.
OBJECTIVE: To review the research concerning leukemia stem cells.
METHODS: A computer-based search was undertaken in Vip database for articles published from January 1989 to January 2010 with the key words of “leukemia stem cells” in Chinese. Simultaneously, Foreign Medical Journal Service was searched for the articles about leukemia stem cells published between January 1995 and January 2010, with the key words of “leukemia stem cells” in English. A total of 154 articles were collected.
RESULTS AND CONCLUSION: With the proposal of leukemia stem cells concept and deep research, the targeted therapy for leukemia stem cells became possible. Through the isolation, purification and identification of leukemia stem cells, experts tried to develop new ways to treat leukemia, which are targeting cellular surface molecules, regulatory mechanisms and microenvironment of leukemia stem cells. Primary results proved that these methods are feasible. However, some confounding factors should be excluded. Animal models are difficult to completely simulate in vivo environment.

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