Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (27): 5095-5098.doi: 10.3969/j.issn.1673-8225.2010.27.036

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Immunological characteristics of adipose-derived stem cells

Han Chang-jie, Yang Xiang-qun, Zhang Chuan-sen   

  1. Department of Human Anatomy, Second Military Medical University of Chinese PLA, Shanghai  200433, China
  • Online:2010-07-02 Published:2010-07-02
  • Contact: Zhang Chuan-sen, Doctor, Professor, Department of Human Anatomy, Second Military Medical University of Chinese PLA, Shanghai 200433, China
  • About author:Han Chang-jie★, Studying for master’s degree, Department of Human Anatomy, Second Military Medical University of Chinese PLA, Shanghai 200433, China hanchangjieyourfirend @yahoo.com.cn
  • Supported by:

    the National Natural Science Foundation of China, No. 30970737*; the Key Foundation for Natural Science of Shanghai City, No. 08441900600*

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Abstract:

BACKGROUND: Due to the immunological rejection caused by allogeneic cells, both of stem cell transplantation and tissue engineering are limited to the scope of individualized treatment and therefore not suitable for treatment of war trauma or extensive clinical use. Adipose-derived stem cells not only have the multiple differentiation potential, but also characterized by their broad sources, enough amount, easy-to-amplification and low immunogenicity. Thus, it is possible to construct heterologous tissue-engineered organs.
OBJECTIVE: To summarize progresses in the immunological characteristics of adipose-derived stem cells.
METHODS: A computer-based online search of VIP, Pubmed and Elsevier databases was performed for related articles with the key words of “adipose-derived stem cells, ADSCs, immunogenicity, immune regulation, implantation”. Articles related to immunological characteristics of adipose-derived stem cells were included, and repetitive studies were excluded.
RESULTS AND CONCLUSION: A total of 26 articles were collected, and 17 were included. At present, the immunological characteristics researches of adipose-derived stem cells mainly focus on the immunophenotype, in vitro and in vivo immunological properties, revealing that adipose-derived stem cells have low immunogenicity and immune regulation property, hopefully to be a candidate for allogeneic stem cell transplantation and tissue engineering products.

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