Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (27): 5090-5094.doi: 10.3969/j.issn.1673-8225.2010.27.035

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Colonization factors of stem cells in myocardial infarction tissues

He Ping1, Li He1, Zhao Yu-sheng2   

  1. 1 Medical College of Chinese Pepole’s Armed Police Force, Tianjin  300162, China; 2 Institute of Geriatric Cardiology, General Hospital of Chinese PLA, Beijing  100853, China
  • Online:2010-07-02 Published:2010-07-02
  • Contact: Zhao Yu-sheng, Professor, Doctoral supervisor, Institute of Geriatric Cardiology, General Hospital of Chinese PLA, Beijing 100853, China zys3012002@yahoo.com
  • About author:He Ping★, Studying for master’s degree, Medical College of Chinese Pepole’s Armed Police Force, Tianjin 300162, China heping2008happy@163.com
  • Supported by:

    the National High Technology Research and Development Program of China*

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Abstract:

BACKGROUND: Pathological changes, such as myocardial lesions or absence, are commonly in heart disease. The myocardial cells are terminal cells that can not regenerate. Thus, it is a hot focus to explore an effective mechanism for myocardial tissue regeneration and repair.
OBJECTIVE: To review the progress of myocardial tissue-engineered materials and the promotive effects of cytokine and Chinese patent medicine on stem cells homing, and to provide a theoretical basis for the study of stem cells differentiate into myocardial cells.
METHODS: Documents in the PubMed and VIP databases from January 2002 to July 2009 were searched by computer using key words of “Stem Cells, Myocardial infarction, Tissue Engineering and Cytokines” both in English and Chinese. Papers related to myocardial regeneration, scaffold materials, revascularization of myocardial tissue, and the effects of cytokine and Chinese patent medicine on stem cells differentiation were included. Repetitive research or Meta analysis was excluded.
RESULTS AND CONCLUSION: Stem cell transplantation has shown attractive prospect in the treatment of myocardial infarction. However, generally, stem cells could seldom enter the peripheral circulation, and it was very limited to repair myocardial necrotic tissue. There were three key issues: induction and differentiation, transplantation and survival, mobilization and homing. Tissue engineering, cytokine, Chinese patent medicine, combined with stem cells transplantation, could be the effective treatment for myocardial infarction. Such problems unsolvable by far would be tackled by mobilization and homing of stem cells. But the research of stem cells just begin now, many puzzles need to be solved.

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