Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (27): 5081-5084.doi: 10.3969/j.issn.1673-8225.2010.27.033

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Lung stem cells and the markers: Source localization and labeled difficulty

Jiang Yi-yao1, Du Zhen-zong1, Wang Hai-yong1, Zhang Zhang2   

  1. 1 Department of Cardiothoracic Surgery, 2 Department of Radiotherapy, Hospital Affiliated to Guilin Medical College, Guilin  541001, Guangxi Zhuang Autonomous Region, China
  • Online:2010-07-02 Published:2010-07-02
  • Contact: Du Zhen-zong, Master’s supervisor, Department of Cardiothoracic Surgery, Hospital Affiliated to Guilin Medical College, Guilin 541001, Guangxi Zhuang Autonomous Region, China duzhenzong@sina. com
  • About author:Jiang Yi-yao★, Studying for master’s degree, Department of Cardiothoracic Surgery, Hospital Affiliated to Guilin Medical College, Guilin 541001, Guangxi Zhuang Autonomous Region, China Jiangyiyao0309@ sina.com

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Abstract:

BACKGROUND: In the definite condition, lung stem cells can differentiate into the functional lung tissue. In recent years, the research about the origin of lung stem cells and its markers has gained homologous progress.
OBJECTIVE: To review the source of lung stem cells in the perspective of endogenous and exogenous lung stem cells, and to summarize the possible lung stem cell markers in representation of Sca-1, ABCG2/Bcrp1, residual cell marker molecules, cell surface molecules, cytokeratin, and CCSP.
METHODS: A computer-based online search of China Journal Full-text Database and Pubmed was performed for articles and reviews in Chinese and English. The key words were “lung stem cells, markers”. A total of 79 articles were retrieved, and screened following reading titles and abstracts. Literatures about lung stem cells and markers were included. Repetitive articles with poor quality were excluded. Finally, 31 literatures were included.
RESULTS AND CONCLUSION: The complexity of the lung tissue determined that the difficulty which was finding out the origin of lung stem cells and its markers. Currently, there are still many further explorations of the unknown fields. With the development of the experimental technique, there will be more and more new discovery. Lung stem cells will have a broad prospect in the clinical application.

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