Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (27): 5077-5080.doi: 10.3969/j.issn.1673-8225.2010.27.032

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Human embryonic stem cells culture and lung regeneration

Wang Lei1, Zhong Hong 1,2   

  1. 1 Department of Cardiothoracic Surgery, Xinhua Hospital, Medical School, Shanghai Jiao Tong University, Shanghai  200092, China; 2 Department of Cardiothoracic Surgery, Xinhua Hospital (Chongming), Medical School, Shanghai Jiao Tong University, Shanghai  202150, China
  • Online:2010-07-02 Published:2010-07-02
  • Contact: Zhong Hong, Doctor, Professor, Chief physician, Master’s supervisor, Department of Cardiothoracic Surgery, Xinhua Hospital, Medical School, Shanghai Jiao Tong University, Shanghai 200092, China; Department of Cardiothoracic Surgery, Xinhua Hospital (Chongming), Medical School, Shanghai Jiao Tong University, Shanghai 202150, China zhonghongyyy@163.com
  • About author: Wang Lei★, Studying for master’s degree, Physician, Department of Cardiothoracic Surgery, Xinhua Hospital, Medical School, Shanghai Jiao Tong University, Shanghai 200092, China wllygjs@126.com

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Abstract:

BACKGROUND: In the field of pulmonary research, studies using human embryonic stem cells have succeeded in generating enriched cultures of type II pneumocytes in vitro. On account of their potential of indefinite proliferation in vitro, embryonic stem cells could be a source of an unlimited supply of cells that are available for transplantation and for use in gene therapy.
OBJECTIVE: To review recent advance on human embryonic stem cell culture and lung regeneration.
METHODS: We retrieved related literatures of China National Knowledge Infrastructure with the key words of “human embryonic stem cells, lung regeneration” from January 2000 to January 2010 in Chinese by computer. We then retrieved related literature of PubMed with the key words of “human embryonic stem cells, lung regeneration” from January 1990 to January 2010 in English by computer. A total of 396 articles were searched.
RESULTS AND CONCLUSION: Because lung tissues have a complex structure and little capacity of regeneration, it is difficult to cure for lung diseases. At present, it is known that human embryonic stem cells are able to differentiate into lung tissue cells directionally; human embryonic stem cells are engrafted into the injured lung tissues, and induced to differentiate into alveolar epithelial cells, and further develop alveolar tissue. This is a promised therapeutic tool, but it remains in the basal research stage.

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