Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (19): 3546-3548.doi: 10.3969/j.issn.1673-8225.2011.19.030

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Distribution of Telocytes in the rat heart

Liu Juan-juan1,2,3, Shen Xiao-tao1,2,3,4, Zheng Xin1,2,3, Li Zhen1,2,3, Wang Jian1,2,3, Qi Xu-feng1,2,3, Cai Dong-qing1,2,3   

  1. 1Key Laboratory for Regenerative Medicine, Ministry of Education, 2Joint Laboratory for Regenerative Medicine, the Chinese University of Hong Kong-Jinan University, 3the International Base of Collaboration for Science & Technology, the Ministry of Science and Technology & Guangdong Province Science and Technology Bureau, 4Department of Biomedical Engineering, Jinan University, Guangzhou  510632, Guangdong Province, China
  • Received:2011-01-16 Revised:2011-03-05 Online:2011-05-07 Published:2011-05-07
  • Contact: Cai Dong-qing, Professor, Doctoral supervisor, 1Key Laboratory for Regenerative Medicine, Ministry of Education, 2Joint Laboratory for Regenerative Medicine, the Chinese University of Hong Kong-Jinan University, 3the International Base of Collaboration for Science & Technology, the Ministry of Science and Technology & Guangdong Province Science and Technology Bureau, Jinan University, Guangzhou 510632, Guangdong Province, China tdongbme@jnu.edu.cn
  • About author:Liu Juan-juan★, Studying for master’s degree, 1Key Laboratory for Regenerative Medicine, Ministry of Education, 2Joint Laboratory for Regenerative Medicine, 3the Chinese University of Hong Kong-Jinan University, the International Base of Collaboration for Science & Technology, the Ministry of Science and Technology & Guangdong Province Science and Technology Bureau, Jinan University, Guangzhou 510632, Guangdong Province, China 05juanjuan@163.com
  • Supported by:

    the National “863” Program, No. 2007AA02Z105*; the National Natural Science Foundation of China, No. 30973158*, 30770886*, 30570369*, 30340038*; Guangdong Natural Science Foundation, No. 04105826*; Guangdong Science and Technology Development Program, No. 2004B30601007*; International Collaborated Program of Guangdong, No.  2009B050900007*; The Fundamental Research Funds for the Central Universities, No. 21609408*

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Abstract:

BACKGROUND: Telocytes in the heart are possible to act as linker and supporting cells between cardiac myocytes and endogenous cardiac stem cells, and play an important role in myocardial regeneration and ventricular remodeling after myocardial infarction (MI). However, the distribution of Telocytes in the heart and their functional role are still unclear.
OBJECTIVE: To investigate the distribution of Telocytes in the rat heart.
METHODS: The continuous frozen sections were conducted using female SD rat heart. The representation sections from the base, the medium, and the atrium-atria of the heart were selected for immunofluorescence staining with c-kit antibody. The c-kit positive and unique morphology of Telocytes were applied as standard to identify the distribution of Telocytes in the rat heart.
RESULTS AND CONCLUSION: The cell density of Telocytes in the base part (26 cells/mm2) and the atrium-atria part (20 cells/mm2) was significantly higher than that in the medium part (9 cells/mm2). In addition, the cell density of Telocytes in the subepicardium (the base: 18 cells/mm2; the medium: 5 cells/mm2; the atrium-atria: 13 cells/mm2) was significantly higher than that in the endocardium (the base: 7 cells/mm2; the medium: 4 cells/mm2; the atrium-atria part: 7 cells/mm2). The above-mentioned results suggested that the distribution of Telocytes in the heart is different. The pattern of Telocytes distribution in the heart may be related to the different distribution of cardiac myocytes and endogenous cardiac stem cells.

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