Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (18): 3311-3314.doi: 10.3969/j.issn.1673-8225.2011.18.020

Previous Articles     Next Articles

Antibody mediated rejection during transplant kidney biopsy

Han Yong, Guo Hui, Huang Hai-yan, Xu Xiao-guang, Cai Ming, Shi Bing-yi   

  1. Military Organ Transplantation Center, the 309 Hospital of Chinese PLA, Beijing  100091, China
  • Received:2010-10-21 Revised:2010-12-10 Online:2011-04-30 Published:2011-04-30
  • Contact: Shi Bing-yi, Master, Professor, Chief physician, Doctoral and Master’s supervisor, Military Organ Transplantation Center, the 309 Hospital of Chinese PLA, Beijing 100091, China shibingyi@medmail.com.cn
  • About author:Han Yong, Associate chief technician, Military Organ Transplantation Center, the 309 Hospital of Chinese PLA, Beijing 100091, China frankbj72@163.com
  • Supported by:

    the National Key Technology R&D Program of China during the Eleventh Five-year Plan, No. 2008BAI60B04*

PDF

432

Abstract:

BACKGROUND: Acute humoral rejection, characterized as hormone resistance and refractory feature, often occurs in immune hypersensitivity recipients.
OBJECTIVE: To observe the effect on antibody-mediated rejection during transplant kidney biopsy and to analyze the safety of transplant kidney biopsy.
METHODS: Eighty-four patients underwent transplant kidney biopsy following renal transplantation. The biopsy was performed using B-ultrasound guided BARD puncture. Hematoxylin-eosin staining, histochemical staining and C4d immunohistochemical staining were performed. All biopsies were systematically diagnosed and evaluated according to the Banf 2005 schema.
RESULTS AND CONCLUSION: Except for 1 case which was difficult to diagnose because of few tissues, there were 1 case of hyperacute rejection, 5 of acute antibody mediated rejection, 2 of chronic antibody mediated rejection, and 16 positive for C4d. After treatment, 4 of 8 antibody mediated rejection cases recovered renal transplantation, 3 did not recover, and 1 lost renal function. There were no adverse effects. The results showed that transplant kidney biopsy is safe and reliable for the assist diagnosis and treatment of renal dysfunction after renal transplantation.

CLC Number: