Abstract:

BACKGROUND: With the rapid development of hematopoietic stem cell transplantation (HSCT) in China over the last 20 years, more and more patients have been cured after allogeneic HSCT; however, few reports discussed the long-term follow-up results of post-transplantation.
OBJECTIVE: To summarize a long-term follow-up after allogeneic HSCT.
METHODS: There were 30 patients who received allogeneic HSCT at the Third Affiliated Hospital of Sun Yat-sen University between 1995 and 2005. We summarized patients’ long-term complications, survival rate and cause of death and investigated quality of life of long-term survival patients.
RESULTS AND CONCLUSION: In 30 cases, the incidence of chronic graft versus host disease was 67%. Each patient suffered from infertility, and one patient had slight pulmonary fibrosis. No other complications were detected. Disease-free survival two years after transplantation was 60%. Patients without relapse could survive for a long time within two years. The longest surviving time was over 14 years. 12 of 30 patients died, and all of those deaths occurred in two years post-transplantation. Five cases died of recurrence, and other seven patients died of infection. Long-term survival patients had poor life quality one year after transplantation, and their life quality gradually improved with prolonged survival time. The quality of life was improved significantly five years post-transplantation, and the quality of life was high at eight years. The main influential factor for quality of life was chronic graft versus host disease.