Biocompatibility of anatomic porous titanium fusion cage

doi:10.3969/j.issn.2095-4344.2016.48.006

Abstract

Abstract:

BACKGROUND: Traditional horizontal cylindrical titanium alloy interbody fusion cage with screw thread can improve the symptoms of patients with degenerative lumbar disease, but the prognosis is poor and fusion rate is low.

OBJECTIVE: To study the biocompatibility of anatomic porous titanium fusion cage and application effect of degenerative lumbar disease.

METHODS: Fifty patients with degenerative lumbar diseases were randomly divided into two groups. Patients in the experimental group (n=25) were treated with anatomic porous titanium fusion cage. Patients in the control group (n=25) were treated with traditional titanium fusion cage. After treatment, fusion rate, intervertebral space height ratio, intervertebral foramen height ratio, inter-vertebral angle activity domain, fusion segment lordosis angle, lumbar lordosis angle, lumbar horizontal angle and sacrohorizontal angle were observed.

RESULTS AND CONCLUSION: Patients were followed up for 6 to 29 months. Fusion rate was significantly higher in the experimental group than in the control group (92%, 68%; P < 0.05). No adverse reactions were seen in the experimental group. Infection and chronic cerebrospinal fluid leakage were found in three cases of the control group. At 3 and 6 months after treatment, intervertebral space height ratio, intervertebral foramen height ratio, inter-vertebral angle activity domain (L_3/4, L_5/5 and L₅/S₁), fusion segment lordosis angle, lumbar lordosis angle, lumbar horizontal angle and sacrohorizontal angle were significantly larger in the experimental group than in the control group (all P < 0.05). These results suggest that anatomic porous titanium fusion cage for treating degenerative lumbar disease has good biocompatibility, and the fusion rate is high.

中国组织工程研究杂志出版内容重点：人工关节；骨植入物；脊柱；骨折；内固定；数字化骨科；组织工程

Key words: Alloys, Spinal Fusion, Tissue Engineering

CLC Number:

R318

A Jian-cuo, Wang Xi-min, Li Zhan-yin, Xu Zhi-hua. Biocompatibility of anatomic porous titanium fusion cage[J]. Chinese Journal of Tissue Engineering Research, 2016, 20(48): 7185-7191.

Figures/Tables 3

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