Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (51): 9629-9634.doi: 10.3969/j.issn.2095-4344.2012.51.024

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Therapeutic implication of nano-hydroxyapatite in orthopedics   

Yang Zai-qing1,2, Lei Yun-kun1,2, Meng Zeng-dong1,2   

  • Online:2012-12-16 Published:2012-12-16

Abstract:

BACKGROUND: Nano-hydroxyapatite is a representative bioactive material, which has been the focus of tissue engineering research.
OBJECTIVE: To review the orthopedic application and mechanism of nano-hydroxyapatite.
METHODS: CNKI and PubMed databases (2001-01/2011-12) were retrieved for articles related to the effect of nano-hydroxyapatite on osteoblasts, osteoclasts, and revascularization to summarize the clinical progress of nano-hydroxyapatite in orthopedics.
RESULTS AND CONCLUSION: Nano-hydroxyapatite can enhance the proliferation activity and functional metabolism of osteoblasts, and induce new bone formation. However, osteoclasts can absorb and degrade hydroxyapatite, and meanwhile, nano-hydroxyapatite can regulate osteoclast's metabolic processes and they influence each other in the bone metabolism. In addition, after implantation, nano-hydroxyapatite can be revascularized quickly and completely that is conducive to bone repairing and rebuilding. In view of the superiorities of nano-hydroxyapatite and its composite materials, nano-hydroxyapatite is an ideal material for repairing bone defects and has been preliminarily used in clinic. But there are still many problems to be solved in the future.