Relationship between lumbar spinal stenosis and inflammatory factors in the vein serum of lumbar spinal canal

doi:10.3969/j.issn.2095-4344.2014.26.024

Abstract

Abstract:

BACKGROUND: Numerous studies have shown that local lumbar stenosis can cause immunological abnormalities and local chronic inflammation, which is the main cause of pain. At present, studies on inflammatory factors and lumbar spinal stenosis mainly focused on intervertebral discs, facet joint and ligamenta flava. No reports addressed the relationship between inflammatory factor in vein of lumbar spinal canal and lumbar spinal stenosis.
OBJECTIVE: To analyze the correlation of serum interleukin-1α and tumor necrosis factor-α levels with lumbar spinal stenosis.
METHODS: A total of 51 patients with lumbar spinal stenosis or lumbar vertebral burst fracture, who underwent posterior lumbar decompression in the Department of Spine Surgery, Shanghai East Hospital, Tongji University in China from September 2011 to December 2013, were enrolled in this study. Visual analogue scale score of low back pain and Oswestry disability index were evaluated before treatment. Peripheral vein blood and venous blood in the vertebral canal were collected from patients with lumbar spinal stenosis or lumbar vertebral burst fracture. The concentrations of serum interleukin-1α and tumor necrosis factor-α were determined using enzyme-linked immunosorbent assay.
RESULTS AND CONCLUSION: The concentration of interleukin-1α in degenerative lumbar stenosis group was significantly higher than that in the lumbar burst fracture group and peripheral veins (P < 0.05). The more segments of lumbar spinal stenosis, the higher the venous serum interleukin-1α levels were in the degenerative lumbar stenosis group, but the statistical difference was not significant. Linear correlation analysis results displayed that interleukin-1α levels were positively associated with low back pain and disability scores in the degenerative lumbar stenosis group (r²=0.359 3, P < 0.05; r²=0.526 4, P < 0.05). These results indicated that the lumbar spinal venous inflammatory factors may be one of the reasons of low back pain and dysfunction in patients with degenerative lumbar spinal stenosis.

中国组织工程研究杂志出版内容重点：人工关节；骨植入物；脊柱；骨折；内固定；数字化骨科；组织工程

全文链接：

Key words: low back pain, spinal stenosis, interleukin-1 alpha, tumor necrosis factor-alpha, pain measurement

CLC Number:

R318

Zhang Yan, Meng Yang, Zhao Wei-dong, Huang Yu-feng, Shen Bin, Wu De-sheng. Relationship between lumbar spinal stenosis and inflammatory factors in the vein serum of lumbar spinal canal[J]. Chinese Journal of Tissue Engineering Research, 2014, 18(26): 4229-4235.

Figures/Tables 7

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