Abstract:

BACKGROUND: Different average molecular weight and molecular weight distribution, as well as different chemical composition and sequence structure of sodium alginate will results in different applications of sodium alginate.
OBJECTIVE: To measure the average molecular weight and molecular weight distribution, as well as different chemical composition and sequence structure of sodium alginate used for tissue-engineered medical products.
METHODS: The average molecular weight and the molecular weight distribution were detected by size exclusion chromatography-multi-angle laser light scattering. The chemical composition and sequence structure were detected by Hydrogen-1 nuclear magnetic resonance.
RESULTS AND CONCLUSION: The sample’s number-average molecular weight was 7.360×10⁴, weight-average molecular weight was 1.031×10⁵ and the molecular weight distribution (Mw/Mn) was 1.401. Fg was 0.405, Fm was 0.595, the M/G was 1.47, Nm was 2.78, Ng was 1.89 and Ng>1 was 2.72.