New biological dermis cover Pelnac® in wound healing of children with severe trauma

doi:10.3969/j.issn.2095-4344.2014.16.023

Abstract

Abstract:

BACKGROUND: In recent years, tissue engineering has made great progress, and skin tissue engineering is especially noteworthy. Artificial dermis (PELNAC) is relatively used widely, but there is a lack of relevant reports on wound repair in children.

OBJECTIVE: To investigate the clinical efficacy of Pelnac^® as skin graft dressings on treatment of the wounds of severe trauma in children.

METHODS: In a retrospective study, 22 patients with the wound of severe trauma were treated with Pelnac^® graft, negative-pressure wound therapy and split-thickness skin graft as experimental group (Pelnac^® group), and another 19 patients treated with granulation formation dressing and split-thickness skin graft as control group. We collected data including the graft livability, the required re-operative times and the epithelization time after the skin graft. During the follow-up, the skin color and texture of survival skin, subcutaneous fullness, scar hyperplasia and the joint function were also evaluated.

RESULTS AND CONCLUSION: In the Pelnac^® group, the graft livability was up to 90% within 10-14 days after grafting. The secondary split-thickness skin graft was required in two cases in the Pelnac^® group and in eight cases in the control group. There was a significant difference in the graft livability (P < 0.05). The average epithelization time after the skin graft was (13.86±3.09) days in the Pelnac^® group, which was significant shorter than the control group, (19.10±4.62) days, after the first time operation (P < 0.05). During the 10 months follow-up, the survival skin color and skin elasticity in the Pelnac^® group was significantly better than that in the control group (P < 0.05). Better subcutaneous fullness and milder scar hyperplasy in the injured sites were obtained in the Pelnac^® group compared with the control gorup. Five cases had certain joint function limitation in the Pelnac^® group, compared to 10 cases in the control group, with a significant difference (P < 0.05). Artificial dermis Pelnac^® has a stronger anti-infectious ability and higher graft livability. Pelnac^® graft combined with negative-pressure wound therapy, granulation culture and split-thickness skin graft can shorten the epithelization time, improve wound healing and alleviate harm to the joint function after the skin graft.

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

全文链接：

Key words: skin transplantation, skin, artificial, negative-pressure wound therapy, wounds and injuries

CLC Number:

R318

Tian Liang, Qiu Lin, Fu Yue-xian, Tian Xiao-fei, Liu Yan, Xiao Jun. New biological dermis cover Pelnac^® in wound healing of children with severe trauma[J]. Chinese Journal of Tissue Engineering Research, 2014, 18(16): 2601-2606.

Figures/Tables 4

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