Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (38): 7131-7134.doi: 10.3969/j.issn.2095-4344.2012.38.021

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Degradability of epsilon-caprolactone and DL-lactide copolymers in vivo

Zhang Wei, Yang Dan, Wang Ping, Wang Ling, Zhen Zhu   

  1. Liaoning Research Institute of Family Planning, Shenyang 110031, Liaoning Province, China
  • Received:2012-01-07 Revised:2012-02-01 Online:2012-09-16 Published:2012-09-16
  • Contact: Yang Dan, Research fellow. Liaoning Research Institute of Family Planning, Shenyang 110031, Liaoning Province, China yangdan0108@ 126.com
  • About author:Zhang Wei★, Master, Researcher, Liaoning Research Institute of Family Planning, Shenyang 110031, Liaoning Province, China zhangweitiny@ sohu.com

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Abstract:

BACKGROUND: Copolymers of ε-caprolactone and DL-lactide (PCDLA) have good biocompatibility and adjustable degradation rate. And there is an important relationship between the application of PCDLA and its degradation property in vivo.
OBJECTIVE: To investigate the degradation property of PCDLA in vivo of big ear rabbits.
METHODS: The PCDLA with different copolymer compositions were made into samples with different sizes, and the samples were implanted in the back of Japanese big ear rabbits subcutaneously. The morphology, weight loss rate, number-average molecular weight and thermal properties of the samples were observed regularly. The degradation property of PCDLA in vivo was evaluated.
RESULTS AND CONCLUSION: The results showed that the PCDLA shape retention was enhanced and degradation rate was slowed down with the feed ratio of ε-caprolactone increased. These suggest that for the same copolymer composition of samples, the larger size, and the faster degradation rate.

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