Abstract:

BACKGROUND: Biological degradation antibiotics drug delivery systems possess some advantages, such as the biological degradation of the carrying materials, complete delivery of the antibiotics, higher density of part drug, better effectiveness of anti-infection and fewer systemic adverse reactions.
OBJECTIVE: To observe the effectiveness of the antibiotics drug delivery systems of the β-tricalcium phosphate sintered bone loading gentamycin for treating chronic osteomyelitis.
METHODS: Forty-eight New Zealand white rabbits were selected to make the model of chronic osteomyelitis, and then randomly divided into experimental group and control group. The antibiotics drug delivery systems of the β-tricalcium phosphate sintered bone loading gentamycin was implanted into the experimental group, and the particles of β-tricalcium phosphate sintered bone were implanted into the defect site of the control group.
RESULTS AND CONCLUSION: The general reactions, wound healing, changing of the white blood cells and C-reactive protein in the venous blood of the experimental group were better than those of the control group. The antibiotics drug concentration in the experimental group could achieve burst release and reach peak at the 1st day postoperation, then maintained a higher concentration that was 10 times higher than its effective bacteriostasis concentration within 4 weeks postoperation; but when there was a higher antibiotics drug concentration in the local tissue, the general drug concentration was lowered. At 3 weeks after operation, the antibiotics drug concentration in the venous blood could not be observed. All of above showed that the antibiotics drug delivery systems of the β-tricalcium phosphate sintered bone loading gentamycin could treat chronic osteomyelitis better.