Abstract:

BACKGROUND: The incidence of osteoporosis is increasing every year, which becomes more and more harmful to the human health. Finding a suitable and effective treatment method and drugs can reduce patients’ and social burden.
OBJECTIVE: To analyze the therapeutic effect of various kinds of nature polysaccharide on osteoporosis, and to clarify the effect and mechanism of polysaccharide intervention on osteoporosis.
METHODS: Animal experiments were performed to analyze the effect of wolfberry polysaccharide, morinda officinalis how polysaccharide, astragalus polysaccharide and polygonatum polysaccharide on the treatment of osteoporosis. A rat model of castration osteoporosis was established. The effect of nature polysaccharide on the treatment of osteoporosis was evaluated through detecting the relevant biochemical markers, such as the bone mineral density, bone calcium content, interleukin-1 level, interleukin-6 level, nitric oxide synthase level and tumor necrosis factor level.
RESULTS AND CONCLUSION: The wolfberry polysaccharide has the therapeutic effect on osteoporosis through adjusting the absorption and excretion of calcium and the expression of nitric oxide level, tumor necrosis factor-α and transforming growth factor-β. Morinda officinalis how polysaccharide plays the therapeutic effect on osteoporosis through adjusting the expression level of interleukin-1 and tumor necrosis factor. Astragalus polysaccharide can be used to treat osteoporosis by adjusting the immune function and hematopoietic function. Polygonatum polysaccharide exerts the therapeutic effect on osteoporosis through adjusting the expression osteocalcin and tartrate-resistant acid phosphatase activity. All the four kinds of nature polysaccharides have the better therapeutic effect in the rat model of castration osteoporosis.