Abstract:

BACKGROUND: Studies have shown that basic fibroblast growth factor plays an important role in bone repair, but the relationship of basic fibroblast growth factor gene polymorphism with bone metabolism in osteoporosis has rarely been reported.
OBJECTIVE: To investigate the correlation of five single nucleotide polymorphisms of basic fibroblast growth factor gene and bone mineral density of Guangxi Zhuang nationality women.
METHODS: A case-control study was carried out in 239 osteopenia patients and 83 matched controls. Genotypes for five loci of basic fibroblast growth factor gene (rs12644427, rs3789138, rs308379, rs308442 and rs3747676) were determined by Multiplex SNaPshot. Broadband ultrasound attenuation (BUA) for the right leg calcaneal was measured by French production of Osteospace dry ultrasound bone densitometer.
RESULTS AND CONCLUSION: rs12644427, rs3789138, rs308379, rs308442 and rs3747676 polymorphisms met with Hardy-Weinberg equilibrium (P > 0.05). Multivariate logistic regression analyses revealed only rs308379 polymorphism remained significantly associated with low bone mass (odds ratio=2.123, 95% confidence interval: 1.004-4.491, P=0.049). The results confirm that, intron 1 rs308379 polymorphism of basic fibroblast growth factor gene and bone mineral density of Zhuang nationality women from Zhuang Autonomous Region have some relevance. The presence of the TT genotype may dominantly increase the risk for reduced bone mineral density. AA genotype has a protective effect on bone mineral density. The data also suggest that the rs308442, rs12644427, rs3789138 and rs3747676 polymorphisms are not associated with the bone mineral density of Zhuang nationality women.