Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (43): 8013-8017.doi: 10.3969/j.issn.2095-4344.2012.43.008

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Effects of “iron nutrient in nanometer” supplementation on hepatic hepcidin mRNA expression after strenuous exercise in rats

Pan Xiao-ling1, Liao Chun-hai1, Pang Yang-kang1, Yang Xiao-ping2   

  1. 1Department of Physical Education , Guangdong Medical College, Zhanjiang 524023, Guangdong Province, China
    2Zhanjiang Institute for Drug Control, Zhanjiang Guangdong 524048, Guangdong Province China
  • Received:2012-01-07 Revised:2012-03-14 Online:2012-10-21 Published:2012-10-21
  • About author:Pan Xiao-ling, Lecturer, Department of Physical Education, Guangdong Medical College, Zhanjiang 524023, Guangdong Province, China panxiaoling1977@ 126.com

Abstract:

BACKGROUND: It is a focus that how to improve the benefit of iron supplement in the human body at high intensity exercise, remain body iron homeostasis and increase hemoglobin level.
OBJECTIVE: To investigate the effects of “iron nutrient in nanometer” supplementation on the expression of hepatic hepcidin mRNA after high intensity exercise in rats.
METHODS: Totally 60 healthy male SD rats were randomly divided into four groups: no-exercise group A (were fed with placebo, n=15), exercise group B (were fed with placebo, n=15), no-exercise group C (“iron nutrient in nanometer” supplementation with lavage method, n=15) and exercise group D (“iron nutrient in nanometer” supplementation with lavage method, n=15).
RESULTS AND CONCLUSION: Compared with group A, the expression of hepatic hepcidin mRNA in rats was increased, but the iron concentration was decreased, and total iron binding capacity in serum was increased; transferring saturation was reduced and the concentration of hemoglobin was decreased in group B. But The expression of hepatic hepcidin mRNA was reduced in group C and group D, and the concentration of serum iron increased, total iron binding capacity in serum, and transferring saturation were increased in group C and group D; the concentration of hemoglobin was decreased in group C and group D, but the decreasing degree in group C was lower than that in group D. These findings suggest that “iron nutrient in nanometer” supplementation can significantly inhibit the expression of hepatic hepcidin mRNA after high intensity load exercise in rats, and increase the absorption for “iron nutrient in nanometer” supplementation; besides, it can improve the level of serum iron and hemoglobin and relieve the decreasing degree of exercise-induced hemoglobin.

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