Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (42): 7883-7886.doi: 10.3969/j.issn.1673-8225.2010.42.022

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Interface binding and mechanical strength of nano-hydroxyapatite/gelatin/polyvinyl-alcohol biocomposites

Wang Feng1, Song En-min2, Guo En-yan1, Zhao Ping1, Lai Qi-hui1   

  1. 1 Shandong Key Laboratory of Glass and Ceramics, Shandong Institute of Light Industry, Jinan   250353, Shandong Province, China; 2 Coal Industry Jinan Design and Research Co., Ltd., Jinan   250031, Shandong Province, China
  • Online:2010-10-15 Published:2010-10-15
  • About author:Wang Feng☆, Doctor, Associate professor, Shandong Key Laboratory of Glass and Ceramics, Shandong Institute of Light Industry, Jinan 250353, Shandong Province, China Wf890916@163.com
  • Supported by:

    Natural Science Foundation of Shandong Province, No. Y2007F33*

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Abstract:

BACKGROUND: Chemical composition of nano-hydroxyapatite is close to the bone inorganic ingredients, has a good biological activity and biocompatibility, and can be used to repair damage hard tissue or lesions, has been widely used in plastic surgery and oral restoration. Its wide application as load-bearing implants is limited due to its brittleness. In recent years, nano- hydroxyapatite/organics composites have been widely investigated.
OBJECTIVE: To review studies on nano-hydroxyapatite/gelatin/polyvinyl-alcohol composites.
METHODS: Databases of Science Direct and CNKI were retrieved between January 1994 and December 2009 using key words of “nano-hydroxyapatite; gel; PVA; composite” in English and in Chinese. Totally 126 related articles were selected. Earlier published, duplicated and similar studies were excluded, 24 articles were summarized.
RESULTS AND CONCLUSION: Interaction between three phases in nano-hydroxyapatite/gelatin/polyvinyl-alcohol composites showed polyvinyl-alcohol acts as a crosslink reagent. Due to increasing formation of chemical bonds and complex network structure in three phases, the interface binding and mechanical properties of nano-hydroxyapatite/gelatin/polyvinyl-alcohol composites were improved. Therefore, polyvinyl-alcohol would be a potential crosslink reagent, avoiding the pollution of aldehyde crosslink reagents.

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