Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (42): 7878-7882.doi: 10.3969/j.issn.1673-8225.2010.42.021

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Drug loading strategies and applications of drug eluting stents

Chen Wen-ping1, Zhan Hong-bing1, Li Zhao-hui2   

  1. 1 College of Materials Science and Engineering, Fuzhou University, Fuzhou   350108, Fujian Province, China; 2 Department of Vascular Surgery, Zhongshan Hospital of Xiamen University, Xiamen   361004, Fujian Province, China
  • Online:2010-10-15 Published:2010-10-15
  • Contact: Zhan Hong-bing, Doctor, Professor, Doctoral supervisor, College of Materials Science and Engineering, Fuzhou University, Fuzhou 350108, Fujian Province, China hbzhan@fzu.edu.cn Li Zhao-hui, Doctor, Associate chief physician, Department of Vascular Surgery, Zhongshan Hospital of Xiamen University, Xiamen 361004, Fujian Province, China zhaohli@xmu.edu.cn
  • About author:Chen Wen-ping★, Studying for master’s degree, College of Materials Science and Engineering, Fuzhou University, Fuzhou 350108, Fujian Province, China wpchen1985@163.com
  • Supported by:

     the Higher Institute Foundation of Fujian Province Science and Technology Bureau, No. 2008F50303*

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Abstract:

BACKGROUND: Undesirable drug release profile, late stent thrombosis associated with polymer and failure to maintain coating integrity are the main current problems in the field of drug eluting stents (DESs). The most original way to address these problems is to change the drug loading strategies including the choice of drug and drug carrier, as well as coating preparation technology.
OBJECTIVE: To review the current loading strategies for DESs and to explore the potential future directions.
METHODS: Databases of Elsevier, ACS and Springerlink were retrieved using key words of “stent, drug, coating” to search papers about the DESs coating published from March 2000 to January 2010. Related papers addressing DESs coatings were selected. Articles published in authority journals were preferred in the same field. Totally 445 literatures were initially searched, according to inclusive criteria, 31 literatures were summarized.
RESULTS AND CONCLUSION: According to the bonding mode between drugs and carriers, the DESs can be divided into physically incorporated, electrostatically attracted and covalently bonded carriers. Various systems of drugs, carriers, coating preparations were discussed from the perspective of drug release profile and anti-restenosis efficiency, which indicated that a relatively desirable release profile can be achieved by careful choice of drug carrier and coating technology based on the physiochemical properties of the drug to be loaded. The potential future directions provided in this paper represented a new clue for optimizing DESs.

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