Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (47): 8885-8888.doi: 10.3969/j.issn.1673-8225.2010.47.036

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Biphasic ceramic-like bioactive bone compounded by bone morphogenetic protein and basic fibroblast growth factor to repair finger bone defects

Wang Fu-ke1, Li Yan-lin2, Wang Guo-liang2, Cao Bin2, Li Xiao-lin2, Chen Jian-ming2, Jin Yao-feng2, Wang Yong-nian2   

  1. 1 Department of Head and Neck Surgery, 2 Department of Orthopaedics, The First Affiliated Hospital of Kunming Medical College, Kunming   650032, Yunnan Province, China
  • Online:2010-11-19 Published:2010-11-19
  • Contact: Li Yan-lin, Professor, Doctoral supervisor, Department of Orthopaedics, The First Affiliated Hospital of Kunming Medical College, Kunming 650032, Yunnan Province, China yanlinli1969@yahoo.com.cn
  • About author:Wang Fu-ke☆, Doctor, Lecturer, Department of Head and Neck Surgery, The First Affiliated Hospital of Kunming Medical College, Kunming 650032, Yunnan Province, China wfk.04@126.com

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Abstract:

BACKGROUND: Biphasic ceramic-like bioactive bone compounded bone morphogenetic protein (BMP) and basic fibroblast growth factor (bFGF) has bone conduction function, it can induce stem cells to differentiate into osteoblasts and have become one of ideal bone graft substitutes for repairing bone defects.
OBJECTIVE: To explore the biphasic ceramic-like bioactive bone complex of BMP and bFGF in the clinical repair of bone phalanx defect.
METHODS: Ten enchondroma patients, at a mean age of 33 years were selected. The tumor size was from 0.3 cm × 0.3 cm × 0.3 cm to 1.0 cm × 0.5 cm × 0.5 cm; tumors were located in the affected finger bone and performed tumor curettage, tumor cavities were stuffed with biphasic ceramic-like bioactive bone, followed by conventional wound suture; The postoperative wound healing, local inflammation, rejection, systemic toxicity, tumor cavity healing and recovery of limb function were observed after operation.
RESULTS AND CONCLUSION: No postoperative wound infection, incisal opening healed well. Mild local inflammatory response was observed, with no rejection or systemic toxicity. All patients were followed up for 6 months, new bone grew into the complex BMP and BFGF biphasic ceramic-like bioactive bone filling areas at 3 months after surgery. Fingers could complete daily activities after 1 month. The complex BMP and BFGF biphasic ceramic-like bioactive bone has good osteogenesis, biological security and compatibility, can be used to repair bone defects.

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