Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (3): 395-398.doi: 10.3969/j.issn.1673-8225.2011.03.004

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Feasibility of eyelid reconstruction with acellular xenogenic dermal matrix

Zhang Xiang-rong1, Zhou Qiong1, Xiao Wei2, Liu De-wu3, Peng Yan3   

  1. 1Department of Ophthalmology, 3Department of Burns, First Affiliated Hospital of Nanchang University, Nanchang   330006, Jiangxi Province, China; 2Department of Ophthalmology, Zhangcha Hospital in Chancheng District of Foshan, Foshan   528000, Guangdong Province, China
  • Received:2010-07-28 Revised:2010-08-29 Online:2011-01-15 Published:2011-01-15
  • About author:Zhang Xiang-rong☆, Doctor, Chief physician, Department of Ophthalmology, First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China zhangxiangrong924@126.com
  • Supported by:

    Science and Technology Plan of Jiangxi Provincial Health Bureau, No. 20071033

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Abstract:

BACKGROUND: Reconstruction of posterior lamella of eyelid is an important and difficult issue in eyelid reconstruction, and tarsal substitute is the focus of the study. Xenogenic acellular dermal matrix as a new tissue engineering material, is being widely studied and applied in the field of burn and plastic surgery at home and abroad.
OBJECTIVE: To observe histocompatibility and histopathological changes of xenogenic (porcine) acellular dermal matrix transplantation for eyelid reconstruction in rabbits.
METHODS: Full skin at 20 cm×20 cm was stripped from healthy little white pigs, for preparation of xenogenic (porcine) acellular xenogenic dermal matrix. Model of rabbit tarsal defect was established in 8 New Zealand rabbits, then acellular dermal matrix was implanted. Samples of implanted materials were collected for histological examination at 1, 2, 3 weeks postoperation under light microscopy.
RESULTS and CONCLUSION: There were no obvious rejection and eyelid deformation observed. One week after implantation, partial inflammatory cells invasion was seen with light microscopy, and the inflammatory cells were reduced noticeably at 2 weeks after implantation, at 3 weeks after implantation, normal fibrous tissue ingrew and gradually split, instead of collagen fibers implanted, the inflammation disappeared. With low immunogenicity, and guidance for the growth of new collagen, the xenogenic acellular dermal matrix may be an ideal material of tarsal substitbutes.

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