Chinese Journal of Tissue Engineering Research ›› 2021, Vol. 25 ›› Issue (在线): 1-.

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Experimental study on treatment of Achilles tendinitis with ultrasound-guided phacoemulsification

Yang Xiaoxiao1, Xu Yuanjing2, Li Wentao1, Wang Wenhao3, Ma Zhenjiang1, Wang Jinwu1, 2    

  1. 1Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedic Surgery, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, 200011, China; 2School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, 200030, China; 3College of Medicine, Southwest Jiaotong University, Chengdu 610031, China
  • Received:2021-06-15 Revised:2021-06-17 Accepted:2021-08-24 Online:2021-01-28 Published:2021-08-26

Abstract: BACKGROUND: Tendinitis is a common chronic disease. At present, conservative treatment and surgical treatment are difficult to cure. A minimally invasive and convenient treatment method that has not been widely used in clinical practice. 
OBJECTIVE: This study explored the feasibility of applying phacoemulsification instrument to treat Achilles tendinitis through the Achilles tendinitis model. 
METHODS:  New Zealand rabbit models of Achilles tendinitis were built by collagenase injection, and treated by ultrasonic emulsification under guidance of B-mode ultrasonic scan in 3 weeks. After 3weeks captivity, biomechanical analysis, hydroxyproline concentration measurement of Achilles tendinitis and HE staining was applied to estimate the tendon repair.   
RESULTS AND CONCLUSION: Three weeks after ultrasonic emulsification treatment, HE staining showed that the disordered arrangement of collagen fibers and the cell condensation in group C were improved compared with group B, while the biomechanical analysis and hydroxyproline concentration showed no amelioration in tendinitis. Ultrasonic emulsification therapy is prospect in tendon repair while it is necessary to further explore and optimize the treatment parameters and modes to improve the application effect in many aspects .

Key words: phacoemulsification, tendinitis, biomechanics, minimally invasive, treatment

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