Abstract:

BACKGROUND: Scholars have established animal models of osteosarcoma through a variety of different methods to further study the pathogenesis of osteosarcoma.
OBJECTIVE: To review the establishing methods of osteosarcoma models, animal models of metastatic pulmonary osteosarcoma as well as the characteristics of these models.
METHODS: A computer-based search of databases about animal models of osteosarcoma was performed, and finally 17 articles were included in result analysis.
RESULTS AND CONCLUSION: Osteosarcoma models are classified into experimental animal models and spontaneous animal models. Current models of osteosarcoma mostly belong to experimental animal models. Methods to establish experimental animal models include radionuclides induction, chemical induction, bio-oncogenic factor induction, allograft and so on. There are three methods to screen metastatic pulmonary osteosarcoma and establish appropriate models: in vivo screening, in vitro screening, in vivo and in vitro screening. Establishment of osteosarcoma cell lines or animal models generally requires repeated in vitro subculture and in vivo screening. Scholars use the same method for model establishment, but their details of the establishing process are different. Therefore, there is no uniform understanding and standards for the stability of established animal models.