Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (36): 6805-6809.doi: 10.3969/j.issn.2095-4344.2012.36.028

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Application and research progress of stem cell transplantation in acute kidney injury

Wang Wei1, Wang Wei-wei2, Zhang Jin-yuan2   

  1. 1Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China;
    2Department of Nephrology, the 455 Hospital of Chinese PLA, Nephrology Center of Nanjing Military Area, Shanghai 200052, China
  • Received:2012-03-01 Revised:2012-05-18 Online:2012-09-02 Published:2012-09-02
  • Contact: Wang Wei-wei, M.D. Associate chief physician, Department of Nephrology, the 455 Hospital of Chinese PLA, Nephrology Center of Nanjing Military Area, Shanghai 200052, China w.vwei@163.com
  • About author:Wang Wei★, Studying for master’s degree, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China genpichong86@126.com

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Abstract:

BACKGROUND: In recent years, stem cell transplantation has become a “hot spot” problem in the treatment of acute kidney injury. A lot of progress has been achieved regarding different sources of stem cells for treatment of acute kidney injury.
OBJECTIVE: To briefly review the experimental study, existing problems and prospective application of stem cells from the aspects of cell biological characteristics, clinical application and different sources of stem cells for treatment of acute kidney injury.
METHODS: The CNKI database and Pubmed database (during 2001-01/2012-02) were used to search the related articles about stem cell transplantation in the treatment of acute kidney injury. The retrieval keywords were “stem cell, transplantation, kidney disease, acute kidney injury” in English and Chinese. There were 205 articles by the initial retrieval. Then 41 articles were remained according to the inclusion criteria.
RESULTS AND CONCLUSION: Stem cell transplantation is a new method of treatment for acute kidney injury, which can improve renal function and accelerate kidney repair. Although there are many issues to be resolved, and stem cell transplantation still has huge potential advantages compared to the traditional methods, which shows promising applications in the field of acute kidney injury.

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