Relationship of neutrophils lymphocyte ratio and red blood cell distribution width with idiopathic facial palsy

doi:10.3969/j.issn.2095-4344.2016.24.020

Abstract

Abstract:

BACKGROUND: Similarly with C-reactive protein, red blood cell distribution width can reflect the inflammatory process. Red blood cells involved in inflammatory process leads to the increase in red blood cell distribution width due to various inflammation factor receptors existing on the surface of red blood cells.
OBJECTIVE: To analyze the relationship between the neutrophils lymphocyte ratio, red blood cell distribution width and the pathogenesis and severity of idiopathic facial paralysis.
METHODS: The severity of idiopathic facial paralysis was assessed using the House and Brackmann Facial Nerve Grading System (HB) and Sunnybrook System (SB) in 30 included patients with idiopathic facial paralysis (disease group). The patients were graded as general (score 30-100) and severe paralysis (score 0-29) according to SB scores, or as mild (grade II/III), moderate (grade IV), severe paralysis (grade V/VI) according to HB grades. In addition, 30 healthy volunteers were selected as control group. Neutrophils lymphocyte ratio (NLR) and red blood cell distribution width (RDW) were compared between groups. The correlation of SB and HB scores with neutrophils lymphocyte ratio (NLR) and red blood cell distribution width was analyzed.
RESULTS AND CONCLUSION: Neutrophils lymphocyte ratio was higher in the disease group than the control group (P < 0.01). A significant difference in red blood cell distribution width was found between different stages of disease severity in patients. Red blood cell distribution width was negatively correlated with SB scores (P < 0.01), while was positively correlated with HB grades (P < 0.01). Our results suggest that (1) neutrophils lymphocyte ratio is increased when idiopathic facial paralysis occurs; (2) red blood cell distribution width is positively correlated with the severity of idiopathic facial paralysis, which indicates that inflammation is involved in the pathogenesis of idiopathic facial paralysis, and red blood cell distribution may be a marker for assessing the severity of idiopathic facial paralysis.

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

Key words: Facial Paralysis, Bell Palsy, Erythrocytes

CLC Number:

R318

Shu Xiang-ning, Ma Yue-wen. Relationship of neutrophils lymphocyte ratio and red blood cell distribution width with idiopathic facial palsy[J]. Chinese Journal of Tissue Engineering Research, 2016, 20(24): 3628-3600.

Figures/Tables 3

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