Construction of rat models of experimental tooth movement: time variation of chewing-like jaw movements after tooth movement

Abstract

Abstract:

BACKGROUND: Tooth movement induced by interactive traction during orthodontic treatment causes regular spontaneous pain, however, the central nervous system conduction pathway and the basic mechanisms of pain are not clear.
OBJECTIVE: To establish rat models of experimental tooth movement and observe the behavioral variation of rat chewing-like jaw movements in unit time after tooth movement.
METHODS: Rats were randomly divided into blank, negative control and model groups. According to modified Colin. K. method, rat models of experimental tooth movement were established in the model group through interactive traction of the rat maxillary anterior and posterior teeth by orthodontic nickel-titanium wires. Rats in the blank group were not subjected to interactive traction treatment. Rats in the negative control group were not imposed corrective force. The behavioral variation of chewing-like jaw movements of rats was detected respectively at 4, 12 hours and at 1, 3, 5, and 7 days after tooth movement. At 1 day after tooth movement, relative variation of chewing-like jaw movements of rats was observed after imposing orthodontic force of 30, 60 and 90 g on movable tooth.
RESULTS AND CONCLUSION: Beginning from 4 hours after tooth movement, the total time of chewing-like jaw movements began to increase, and the time of chewing-like jaw movements was significantly increased at 12
hours after tooth movement, reached the peak at 1 day after tooth movement, and then was slowly declined until 7 days in the model group compared with that in the negative control and blank groups. At 1 day after tooth movement, there was significant difference in the time taken for chewing-like jaw movements in the model group among orthodontic force of 30, 60 and 90 g (P < 0.05). These results confirm that the time variation of chewing-like jaw movements after tooth movement is consistent with the rule of pain induced by tooth movement during clinical orthodontic treatment, which can be used as one of the related behavioral responses of oral and maxillofacial pain after tooth movement in rats.

中国组织工程研究杂志出版内容重点：肾移植；肝移植；移植；心脏移植；组织移植；皮肤移植；皮瓣移植；血管移植；器官移植；组织工程

Li Hong-shi, Chen Xin, Feng Yan, Liu Hong-chen. Construction of rat models of experimental tooth movement: time variation of chewing-like jaw movements after tooth movement[J]. Chinese Journal of Tissue Engineering Research, 2015, 19(49): 7988-7993.

Figures/Tables 2

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