Abstract:

BACKGROUND: Currently, the antithrombotic are commonly used for the prevention of venous thromboembolism after total hip arthroplasty, but there is still a certain incidence of venous thromboembolism. Is it possible to reduce the incidence of venous thromboembolism better while not increasing the risk of bleeding if some drugs are applied combinedly before and after operation?
OBJECTIVE: To compare the efficacy and safety of preventing venous thromboembolism after total hip arthroplasty by applying preoperation vitamin E combined with postoperation rivaroxaban versus postoperation rivaroxaban alone.
METHODS: Totally 3 656 patients undergoing total hip arthroplasty in four hospitals, including Affiliated Yidu Central Hospital of Weifang Medical University from January 2010 to March 2012 were randomly divided into experimental group (n=1 830) and control group (n=1 826). The experimental group was given preoperation vitamin E combined with postoperation rivaroxaban therapy, while the control group was given preoperation placebo combined with postoperation rivaroxaban therapy.
RESULTS AND CONCLUSION: Compared with the control group, the incidence of total venous thromboembolism event was lower in the experimental group (P < 0.01), but the incidence of major bleeding event was approximate in two groups (P > 0.05). It indicates that preoperation vitamin E combined with postoperation rivaroxaban can be more effective after total hip arthroplasty than only postoperation rivaroxaban applying in preventing venous thromboembolism, without an extra risk of bleeding.