Abstract:

BACKGROUND: In clinical orthopedic research, a variety of femoral head necrosis animal models have emerged in order to study the etiology and pathogenesis of femoral head necrosis and give a fundamental treatment.
OBJECTIVE: To give a review to the variety of femoral head necrosis improved model established by scholars in recent years, and to analyze the pros and cons of various models, in order to help to study the osteonecrosis pathogenesis or evaluate the clinical value of a new treatment.
METHODS: The CNKI database and PubMed database (2005-01/2011-12) were used to retrieve the articles on the establishment of femoral head necrosis animal models with the key words of “femoral head necrosis, animal model” in English and Chinese. A total of 136 articles were obtained and finally 16 articles were included to review according to the inclusion criteria.
RESULTS AND CONCLUSION: The improved methods of steroid-induced are most used in modeling approach currently, but different modeling approach has its own advantages and disadvantages. Each method should be closely linked with its experimental purpose. And no matter for the study of the etiology and pathogenesis, or the evaluation of treatment, the methods to establish the animal model still needs further improvement.