Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (44): 8271-8278.doi: 10.3969/j.issn.2095-4344.2012.44.020

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Blood inflammatory markers for the diagnosis of joint prosthesis infection

Xie Qiang, Lei Guang-hua   

  1. Department Orthopedic Surgery, Xiangya School of Medicine, Central South University, Changsha 410008, Hunan Province, China
  • Received:2012-07-11 Revised:2012-07-17 Online:2012-10-28 Published:2012-10-28
  • Contact: Lei Guang-hua, Doctor, Professor, Chief physician, Doctoral supervisor, Department Orthopedic Surgery, Xiangya School of Medicine, Central South University, Changsha 410008, Hunan Province, China lgh9640@sina.com
  • About author:Xie Qiang★, Studying for master’s degree, Department Orthopedic Surgery, Xiangya School of Medicine, Central South University, Changsha 410008, Hunan Province, China 554398579@qq.com

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Abstract:

BACKGROUND: Artificial joint replacement as a proven treatment method is now widely used at home and abroad, and the joint prosthesis infection is one of the serious complications of artificial joint replacement surgery. Once the infection occurred, patients will have serious consequences. At present, there is no clinical or laboratory tests that people is satisfied at the sensitivity, specificity and accuracy.
OBJECTIVE: To discuss and summarize the blood inflammatory markers diagnostic methods of prosthesis infection after artificial joint replacement.
METHODS: First author searched the literature from CNKI database (2002/2012) and PubMed database (2002/2012) with the key words of “joint replacement, prosthesis infection, diagnosis, laboratory tests” in Chinese or English. The introduction and summary literatures that related to clinical manifestation and diagnosis of prosthesis infection after joint replacement were searched. A total of 153 literatures were screened out, and 30 literatures were included according to the inclusion and exclusion criteria.
RESULTS AND CONCLUSION: The results showed that serum interleukin-6 levels have the highest accuracy for the diagnosis of joint prosthesis infection, followed by C-reactive protein, erythrocyte sedimentation rate, leukocyte count. However, the routine examination of interleukin-6 is limited, to further assess the accuracy of interleukin-6 and other cytokines for the diagnosis of joint prosthesis infection in different patients also need more in-depth research.

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