Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (41): 7762-7767.doi: 10.3969/j.issn.2095-4344.2012.41.032

Previous Articles     Next Articles

Research and application of seeded cells in reconstruction of jawbone defects

Zou Wei1, Liu Hui-tong1, Li Teng1, Wang Min2   

  1. 1Medicine College of Xi’an Jiaotong University, Xi’an 710061, Shaanxi Province, China
    2Department of Orthopedics, the First Affiliated Hospital, Medicine College of Xi’an Jiaotong University, Xi’an 710061, Shaanxi Province, China
  • Received:2012-03-25 Revised:2012-05-10 Online:2012-10-07 Published:2012-10-07
  • Contact: Wang Min, Professor, Master’s supervisor, Chief physician, Department of Orthopedics, the First Affiliated Hospital, Medicine College of Xi’an Jiaotong University, Xi’an 710061, Shaanxi Province, China
  • About author:Zou Wei, Medicine College of Xi’an Jiaotong University, Xi’an 710061, Shaanxi Province, China zouwei131@foxmail.com

PDF

488

Abstract:

BACKGROUND: The morphology as well as the establishment of occlusal relationship should be considered during the construction of jawbone defects.
OBJECTIVE: To summarize the research status of seeded cells of bone tissue engineering applied to the treatment of jawbone defects in recent years.
METHODS: A computer-based online search was conducted in PubMed database and CNKI database for the relate articles published from June 1994 to April 2011 with the key words “bone tissue engineering, seeded cells, osteogenic differentiation” in Chinese and English. The irrelevant or repetitive articles were eliminated by reading the titles and abstracts. A total of 58 articles were selected to review.
RESULTS AND CONCLUSION: This paper has comprehensively analyzed the current research of various seeded cells used in bone tissue engineering, bone marrow stromal stem cells are most studied, and the research on umbilical cord blood mesenchymal stem cells and umbilical cord mescenchymal stem cells is also popular as scholars can overcome the application disadvantages of mesenchymal stem cells. Embryonic stem cells are expected to become the important seeded cells in bone tissue engineering for repair of jawbone defects if there are no ethical problems. Genetically modified seed cells can enhance the proliferation and directed osteogenic differentiation capacity of seeded cells in bone tissue engineering. But genetic engineering technique is still needed to be improved, and its safety and effectiveness need further discussion.

CLC Number: