Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (41): 7752-7761.doi: 10.3969/j.issn.2095-4344.2012.41.031

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Application of endothelial progenitor cells in the treatment of ischemic cerebrovascular disease

Zhao Rui, Huang Qing-hai, Zhao Wen-yuan, Hong Bo, Xu Yi, Liu Jian-min   

  1. Department of Neurosurgery, Changhai Hospital of Shanghai, Shanghai 200433, China
  • Received:2012-02-06 Revised:2012-07-19 Online:2012-10-07 Published:2012-10-07
  • Contact: Liu Jian-min, Professor, Chief physician, Doctoral supervisor, Department of Neurosurgery, Changhai Hospital of Shanghai, Shanghai 200433, China chstroke@163.com
  • About author:Zhao Rui☆, M.D., Attending physician, Department of Neurosurgery, Changhai Hospital of Shanghai, Shanghai 200433, China z_ray1979@126.com

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Abstract:

BACKGROUND: Previous studies have found that bone marrow and peripheral blood endothelial progenitor cells play an important role in angiogenesis in the adult under pathological conditions. There was the formation of new blood vessels in the ischemic area after cerebral infarction, so endothelial progenitor cells were also involved in this process. The increase of endothelial progenitor cells numbers, as well as the maximum degree of participation in the organization of new blood vessels, provides an important way for the treatment of cerebrovascular disease.
OBJECTIVE: To multivariately analyze the literature on the application of endothelial progenitor cells in the treatment of cerebrovascular disease through SCI database and CNKI database in order to understand the trend of endothelial progenitor cells in the treatment of cerebrovascular disease, the characteristics of endothelial progenitor cells, and the role of data analysis and its application in patients with cerebrovascular disease progress.
METHODS: A retrieval was performed for the literature of the application of endothelial progenitor cells in the treatment of cerebrovascular disease, using key words “endothelial progenitor cells, precursor cell, stroke, brain ischemia or cerebral ischemia, cerebral infarction, ischemic cerebral vascuIar disease” during 2002-01 and 2011-12 in Scopus database and CNKI database. The retrieval results were analyzed, and the trends were described in words and graphics.
RESULTS AND CONCLUSION: Endothelial progenitor cells are bone marrow precursor cells in adults, which can migrate to the peripheral blood and differentiate into mature endothelial cells. They have proliferative potential and can participate in the vascular endothelial repair and new blood vessel formation in ischemic organs. According to the biological properties and role of endothelial progenitor cells, the present study found that endothelial progenitor cells can prevent cerebral artery atherosclerosis, and angiogenesis after focal cerebral ischemia, the forecast evaluation of cerebral ischemic disease, and cerebral hemorrhage after treatment. Thus, endothelial progenitor cells in the treatment of cerebrovascular disease show a wide range of applications.

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