Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (41): 7747-7751.doi: 10.3969/j.issn.2095-4344.2012.41.030

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Research advances in mechanisms by which bone marrow stem cells improve myocardial function

Yu Gui-ping, Shen Zhen-ya   

  1. Department of Cardiothoracic Vascular Surgery, Affiliated Jiangyin Hospital of Medical School of Southeast University, Jiangyin 214400, Jiangsu Province, China
  • Received:2012-01-06 Revised:2012-04-28 Online:2012-10-07 Published:2012-10-07
  • About author:Yu Gui-ping☆, Studying for doctorate, Attending physician, Department of Cardiothoracic Vascular Surgery, Affiliated Jiangyin Hospital of Medical School of Southeast University, Jiangyin 214400, Jiangsu Province, China xiaoyuer97103@163.com

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Abstract:

BACKGROUND: Bone marrow mesenchymal stem cells transplantation can significantly improve the cardiac structure reconfiguration and cardiac function through affecting the myocardial cell formation and myocardial angiogenesis.
OBJECTIVE: To summarize the theoretical basis of bone marrow mesenchymal stem cells transplantation for the treatment of ischemic cardomyopathy through researching the effect of bone marrow mesenchymal stem cells transplantation on myocardial function.
METHODS: The Chinese Biomedical Literature database and Medline database from 1994 to 2011 were used to search the reviews and reports that relate to the application of bone marrow mesenchymal stem cells transplantation for the treatment of ischemic cardomyopathy, and the research progress was analyzed.
RESULTS AND CONCLUSION: A total of 37 articles were included for the review. Autologous application of bone marrow mesenchmal stem cells transplantation can be amplified in vitro without immune rejection and can avoid the ethical controversy. Research of bone marrow stem cells for the treatment of acute myocardial infarction is still in the early stage. With the development of the research, bone marrow mesenchymal stem cells become a new method for the treatment of ischemic cardiomyopathy if we can find an effective and safe dosage.

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