Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (6): 1098-1102.doi: 10.3969/j.issn.1673-8225.2011.06.033

Previous Articles     Next Articles

Therapeutic effect of bone marrow stromal stem cells differentiating into myocytes and its transplantation applications

Wang Yang1, Shen Hui-juan2, Zhou Min-fen1, Zhu Qun-e3, Ye Xian-cai3, Zeng Xian-zhi3   

  1. 1Department of Clinical Medicine, 2Electrical Engineering Center, 3Department of Anatomy, School of Medicine, Jiaxing University, Jiaxing  314001, Zhejiang Province, China
  • Received:2010-09-22 Revised:2010-12-20 Online:2011-02-05 Published:2011-02-05
  • Contact: Zeng Xian-zhi, Doctor, Lecturer, Department of Anatomy, School of Medicine, Jiaxing University, Jiaxing 314001, Zhejiang Province, China frankzengxzh@yahoo.cn
  • About author:Wang Yang, Department of Clinical Medicine, Jiaxing University, Jiaxing 314001, Zhejiang Province, China wydc88@sina.com
  • Supported by:

    the Science and Technology Innovation Project of Zhengjiang Provincial College Students, No.2009*

PDF

428

Abstract:

BACKGROUND: Bone marrow stromal stem cells (BMSCs) are stem cells with the capacity of differentiating into all kinds of myocytes under suitable condition in vitro, and can improve the allomeric function of cardiac or skeletal muscle after transplantation. How to optimize induction and differentiation method to improve transplantation path and the mechanism of tissue function after transplantation has been a hot research spot.
OBJECTIVE: To review researches on inducing BMSCs to differentiate into myocytes and transplanting it to treat myocytes necrotic desease including myocardial infarction and muscular atrophy during recent years.
METHODS: Taking “bone marrow cell, muscle cell” in English as search terms, Pubmed database from 2005 to 2010 was retrieved; Taking “bone marrow stromal stem cells, myocytes” in Chinese as search terms, CNKI database from 2007 to 2010 was retrieved; Taking “bone marrow stromal stem cells, myocytes, differentiation, cardiac” in Chinese as search terms, Wanfang database from 2007 to 2010 was retrieved. A total of 220 literatures addressing peripheral blood stem cells were collected, including 61 Chinese articles and 159 English articles. Published early, repetitive, and similar researches were excluded. Totally 21 articles were included.
RESULTS AND CONCLUSION: BMSCs can be proliferated in vitro, but its specific surface markers have not been identified definitely. So it remains difficulties to obtain fully purified BMSCs. At present, only STRO-1 is one of stromal stem cells’ specific surface antigens, and can be used in identifying and isolating the stromal stem cells in bone marrow. Many studies show that BMSCs can be induced to differentiate into all kinds of tissue cells, including cadiocytes and skeletal muscle cells, through revulsive in vitro and transplantation in vivo. Meanwhile, the improvement of muscular tissue function can be observed after transplantation, but its mechanism remains uncertain. In addition, although the results of differentiation of BMSCs with a variety of induction methods is positive, and transplantation in vivo also shows the potential of necrotic muscle tissue function is improved, the level of induction in vitro is still low, and the function improvement after transplantation in vivo is also limited. Therefore, It is necessary to do further researches on how to improve induction methods to enhance transplantation efficiency and the function improvement.

CLC Number: