Abstract:

BACKGROUND: CT angiograph needs that the contrast media injects into vein, and the greater the dose of contrast media, the greater the hazard to patients.
OBJECTIVE: To validate the feasibility of low dose contrast media in spiral CT pulmonary artery angiograph. 
METHODS: A total of 12 healthy canis familiaris with reference to iohexol dose of human in clinic, according to “equivalent dose conversion of animals and between animals and humans in pharmacological experiments”, which got the corresponding three dose groups: iohexol 2.40 mL/kg group, iohexol 2.02 mL/kg group, iohexol 1.62 mL/kg group. Twelve canis familiaris were treated with 3 kinds of doses for once; scan interval of each experiment was at least 48 hours, a total of 36 CT scans. Pulmonary artery branch conditions, pulmonary vein edge clarity, and filling degree of pulmonary vein of 3 proposals were scored by original image, volume recurrence image, and maximum intensity projection image, and the concentration of contrast media in pulmonary artery was measured
RESULTS AND CONCLUSION: Three kinds of proposals can clearly show 4 branches of canines’ pulmonary artery, the edge of vascular is clear. There was no significant difference in each group (P > 0.05). The degree of pulmonary vein imaging was lowered, and had a good density comparison with pulmonary artery; there was no significant difference in each group (P > 0.05). The concentration of contrast media in pulmonary artery maintained at a high level, there was no significant difference (P> 0.05). It is indicated that it is feasible to use low dose contrast media in multislice spiral CT pulmonary artery angiograph of canines, the image quality can meet the clinical diagnostic requirements to provide the experimental basis of pulmonary artery angiograph with low dose contrast media for clinical application.