Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (4): 615-619.doi: 10.3969/j.issn.1673-8225.2011.04.011

Previous Articles     Next Articles

Meta-analysis of association between Asporin polymorphism and osteoarthritis

Jiang Xiao-hong1, Xiao Zeng-ming1, Jiang Jun-jun2, Li Shi-de1   

  1. 1Department of Spinal and Bone Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China
    2Department of Epidemiology, Public Health of Guangxi Medical University, Nanning  530021, Guangxi Zhuang Autonomous Region, China
  • Received:2010-08-10 Revised:2010-10-16 Online:2011-01-22 Published:2011-01-22
  • Contact: Xiao Zeng-ming, Master, Chief physician, Department of Spinal and Bone Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China
  • About author:Jiang Xiao-hong★, Studying for master’s degree, Department of Spinal and Bone Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China 285278504@qq.com

PDF

421

Abstract:

BACKGROUND: Epidemiologic studies have shown that osteoarthritis has genetic predisposition. Osteoarthritis-related predisposing genes have been discovered. There are studies focusing on osteoarthritis and Asporin polymorphism in Greece, UK, Spain, China and Korea. However, the results vary.
OBJECTIVE: To assess the association between Asporin polymorphism and osteoarthritis using Meta analysis.
METHODS: Related articles were searched from PubMed, EMBASE, Cochrane library in English and from Wanfang, VIP, CBM in Chinese published by from January 2000 to July 2010, with key words “osteoarthritis, Asporin” in English and “osteoarthritis，Asporin, gene” in Chinese. A total of 48 relevant articles were collected which met the criteria and Hardy-Weinberg(H-w) genetic laws. The correlated index was extracted for analysis in RevMan 5.0.
RESULTS AND CONCLUSION: Finally, 6 were included, involving 1 560 patients with knee osteoarthritis and 2 672 controls; 1 800 patients with hip osteoarthritis and 1 416 controls. Of knee osteoarthritis patients, D14/others genotype exhibited OR value=1.23, 95% CI (0.94-1.61), P > 0.05; and D13/others: OR=0.90, 95%CI (0.76-1.06), P > 0.05. Subgroup analysis showed that the P of D14/others and D13/ others > 0.05 in Asian group, while in European group the P of 14/others > 0.05; the OR values of D13/others were 0.83, 95%CI (0.72-0.95), P < 0.05. Of hip osteoarthritis patients, D14/others and D13/others exhibited   P values > 0.05. Results suggest no association between Asporin and knee or hip osteoarthritis, but the recessive protective effects were observed for the D13 allele in knee European populations.

CLC Number: