Abstract:

BACKGROUND: With a large number of applications of iodine contrast agent in enhanced CT examination, the adverse reaction has also been attracted a widespread attention. Under the premise of without affecting the diagnostic quality of CT images, the use of low concentration and low dose iodine contrast agent reducing the toxic reactions of the body have important research value.
OBJECTIVE: To verify the feasibility of low concentration and low dose iodine contrast agent in carotid artery imaging of canine.
METHODS: Three different concentrations of iodine contrast medium (370 mgI/mL, 350 mgI/mL, 300 mgI/mL) were divided into 9 experimental groups (high dose, medium dose, and low dose groups). Three canis familiaris were received multi-slice spiral CT angiography carotid artery imaging repeated sweep, 8 times scanning for each group. The original data were undergoing three-dimensional reconstruction, including volume reconstruction and multi-planar reconstruction; two-dimensional imaging, including maximum intensity projection and surface reconstruction. Vascular edge and development of vascular branches were scored by two radiologists.
RESULTS AND CONCLUSION: The score results showed that the vascular edge (score > 2 points) and the development of vascular branches (score > 3 points) display good in canine carotid artery imaging. The edge of canine carotid artery imaging and the branch carotid artery imaging have strong consistency, the Kappa values were 0.799, 0.733, respectively. There was no significant difference between the edge of artery and branch artery imaging of pairwise comparison in 9 experimental groups (P > 0.05). It is indicated that the application of low concentration and low dose iodine contrast agent can obtain good multi-slice spiral CT canine carotid artery CTA angiography image.