Abstract:

BACKGROUND: Amniotic membrane transplantation has been commonly used in ocular surface reconstruction, it provides a new means for the treatment of early chemical injuries in eyes. But the specific choice of amniotic membrane has not yet standardized, its clinical results reported have some differences.
OBJECTIVE: To compare the clinical efficacy of fresh amnion and biological amnion transplantation for the treatment of early eyeburn injuries.
METHODS: A total of 66 patients (66 eyes) with early burn injuries were randomly divided into fresh amnion group and biological amnion group, with 33 cases in each group, they received fresh amnion transplantation and biological amnion transplantation respectively. All patients were followed up for 3 months after surgery, and the visual acuity, graft survival, complications were observed and compared.
RESULTS AND CONCLUSION: The postoperative visual acuity of both groups improved significantly (P < 0.05); there were 2 cases and 3 cases of fresh amnion group and biological amnion group respectively occurred early dissolution and loss of amnion, and they were cured after the second transplantation. The incidence of complications such as keratoleukoma, corneal macula and corneal neovascularization had no significant difference between the two groups (P > 0.05). Both fresh amnion and biological amnion transplantation can be effective for the treatment of early ocular injuries and ocular surface reconstruction, the efficacy has no significant difference between the two methods.