Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (47): 8847-8849.doi: 10.3969/j.issn.1673-8225.2010.47.026

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Progress in the application of layered double hydroxide in bioengineering

Zhao Jian-zhi1, Yang Qin-zheng1, Zhang Hai-guang2   

  1. 1 Department of Food and Bioengineering, Shandong Institute of Light Industry, Jinan   250353, Shandong Province, China; 2 College of Life Science, Shandong University, Jinan   250100, Shandong Province, China
  • Online:2010-11-19 Published:2010-11-19
  • Contact: Yang Qin-zheng, Doctor, Associate professor, Master’s supervisor, Department of Food and Bioengineering, Shandong Institute of Light Industry, Jinan 250353, Shandong Province, China yangqinzheng@sina.com
  • About author:Zhao Jian-zhi★, Studying for master’s degree, Department of Food and Bioengineering, Shandong Institute of Light Industry, Jinan 250353, Shandong Province, China zhjzh_2006@126.com
  • Supported by:

     the National High-Tech Research and Development Program of China. No.2007AA10Z334*

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Abstract:

BACKGROUND: Layered double hydroxide is an inorganic nano-material which has the properties of good biocompatibility and biodegradability. At present, many drugs and layered double hydroxide successfully form intercalation compound and obtain expected results.
OBJECTIVE: To review research progress and application of layered double hydroxide in bioengineering field.
METHODS: A computer search was mainly performed among articles published from 2003 to 2010 with the Chinese and English key words of “nanotechnology, drug carrier, layered double hydroxide, gene, gene therapy, biosensor, targeting drug delivery”, and a library search was carried out as an assist. Researches about application of layered double hydroxide as drug (gene) carrierand biosensor in bioengineering were included. Researches on little related to theme and physicochemical properties about layered double hydroxide were excluded.
RESULTS AND CONCLUSION: Research shows that intercalation compound not only controls release, but also improves stability for drugs (genes) with toxic and side-effect, and instable chemical property. So, layered double hydroxide is a “green” carrier material with greatly development potential. But, research on layered double hydroxide in bioengineering is confined to laboratory, and researchers must make hard work for clinical application.

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