Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (47): 8843-8846.doi: 10.3969/j.issn.1673-8225.2010.47.025

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Research progress of focal adhesions in cell biomechanics

Feng Zhi-yuan, An Xiao-li, Zhang Bao-ping, Ma Hai-bing, Wang Jing, Liu Bin　   

  1. College of Stomatology, Lanzhou University, Lanzhou   730000, Gansu Province, China
  • Online:2010-11-19 Published:2010-11-19
  • Contact: Liu Bin, Doctor, Professor, College of Stomatology, Lanzhou University, Lanzhou 730000, Gansu Province, China liubkq@lzu.edu.cn
  • About author:Feng Zhi-yuan★, Studying for master’s degree, College of Stomatology, Lanzhou University, Lanzhou 730000, Gansu Province, China fzyfzylzu@126.com
  • Supported by:

    Youth Interdisciplinary Innovation Fund of Lanzhou University, No. lzujc200922*; Open Project of State Key Laboratory of Solid Lubrication, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, No. 0808*; College Students Innovative Experimental Projects by the Ministry of Education, No. LZUYX200625*; General Program of Special Fund for Central University Basic Expenses, No. lzujbky-2009-96*

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Abstract:

BACKGROUND: Focal adhesions have achieved many progresses in the biomechanical field, but the research is still at an early stage, facing the difference between theoretical model and experimental observations, some models lack experimental evidence and further optimizing.
OBJECTIVE: To summarize recent research and related progress on focal adhesions biomechanics.
METHODS: A computer-based online search of CNKI database from January 1995 to April 2010, PubMed database and Elsevier (ScienceDirect) database from January 1975 to April 2010, was performed with key words of “cell adhesion, focal adhesions, adhesion strength, cell mechanics, molecular bond, flexible interface” both in Chinese and English. Literatures concerning focal adhesions in cell biomechanics were included, repetitive research was excluded.
RESULTS AND CONCLUSION: A total of 109 articles were screened out, 64 of them were excluded due to unrelated study objective and repeated contents, finally 45 articles were involved in further analysis. At present, studies on focal adhesions mainly focus on the biomechanical properties of adhesion plaques, the interactions between focal adhesions and cytoskeleton, the size of focal adhesions and adhesion strength, flexible interface and adhesion. With the cell biology, molecular biology and mathematical modeling of the finite element analysis method develop, bio-mechanics study of adhesion plaque will have a new space. Focal adhesion modeling method is further improved and closer to the biological experimental data, the mechanical problems related to focal adhesion is also a new discovery, the focal adhesion biomechanical research can help to establish and analyze other biological micro-models, as well as to understand the mechanism underlying cell adhesion and invasion of tumor cells from the mechanical point of view.

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