Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (2): 196-200.doi: 10.3969/j.issn.1673-8225.2010.02.002

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Effect of compound vibration on bone quality of ovariectomized rats

Deng Xuan-geng1, Chen Jian-ting2, Feng Ying3   

  1. 1 Department of Spine, Sichuan Provincial Orthopedics Hospital, Chengdu  610041, Sichuan Province, China; 2 Department of Orthopaedics & Spine, Nanfang Hospital, Southern Medical University, Guangzhou  510515, Guangdong Province, China; 3 Medical School of Jinggangshan University, Ji’an 393000, Jiangxi Province, China
  • Online:2010-01-08 Published:2010-01-08
  • Contact: Chen Jian-ting, Professor, Chief physician, Doctoral supervisor, Department of Orthopaedics & Spine, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong Province, China
  • About author:Deng Xuan-geng, Physician, Department of Spine, Sichuan Provincial Orthopedics Hospital, Chengdu 610041, Sichuan Province, China tigerd@163.com

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Abstract:

BACKGROUND: Whole body vibration which is used to prevent and treat osteoporosis recently is uncomfortable due to its strong vibration strength. The designed compound vibration with low vibration strength could effectively prevent bone quality decrease of ovariectomized rats.
OBJECTIVE: To verify the effect of compound vibration with low vibration strength on the bone quality of ovariectomized rats.
METHODS: A total of 32 4-month-old female SD rats were used in this study. All SD rats were randomly divided into 4 groups: normal control group, ovariectomized control group, vibration Ⅰ group (45 Hz-55 Hz, 0.05 g-0.1 g), and vibration Ⅱ group
(45 Hz-55 Hz, 0.12 g-0.21 g), with 8 rats for each group. The intervention to each vibration group was one a day, 20 minutes/times, and 5 days per week. The resting interval was shorted than 2 days, and the whole vibration intervention lasted 13 weeks. Bone mineral density (BMD) before and after vibration, ex vivo bone microstructure parameters and biomechanics parameters were measured in this study.
RESULTS AND CONCLUSION: Lumbar BMD of ovariectomized control group was decreased (P < 0.05), but the BMD in the normal control group and the two vibration groups was increased significantly. Femoral BMD of all groups was increased, but there was no significant difference among the four groups. Bone microstructure parameters of the three ovariectomized groups were decreased; however, parameters including number, thickness and distance of bone trabecula and bone volume fraction in the vibration II group were significantly improved compared to ovariectomized control group. Moreover, bone strength of lumbar vertebra in the two vibration groups was significantly increased (P=0.025, 0.006), but there was no significant difference compared to normal control group. Compound vibration with low strength could effectively prevent BMD decrease of ovariectomized rats, lighten the degree of bone microstructure damage, keep bone strength, improve bone quality of ovariectomized rats, and potentially prevent osteoporosis.

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