Chinese Journal of Tissue Engineering Research ›› 2016, Vol. 20 ›› Issue (9): 1353-1360.doi: 10.3969/j.issn.2095-4344.2016.09.020

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System evaluation of unilateral and bilateral pedicle screw fixation and posterior lumbar interbody fusion in the repair of lumbar degenerative diseases

Zhong Yuan-ming, Fu Shuan-hu, Li Zhi-fei, Wu Liang, Zhou Jin-yan, Mo Yi, Lu Da-han   

  1. First Department of Orthopedics, First Affiliated Hospital, Guangxi University of Traditional Chinese Medicine, Nanning 530023, Guangxi Zhuang Autonomous Region, China
  • Online:2016-02-19 Published:2016-02-19
  • About author:Zhong Yuan-ming, Master, Professor, Chief physician, Master’s supervisor, First Department of Orthopedics, First Affiliated Hospital, Guangxi University of Traditional Chinese Medicine, Nanning 530023, Guangxi Zhuang Autonomous Region, China
  • Supported by:

    the Science Research and Technology Development Project of Guangxi Zhuang Autonomous Region, No. 1140003B-56

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Abstract:

BACKGROUND: At present, the internal fixation and fusion surgical treatment of lumbar degenerative disease tends to diversify, but posterior lumbar interbody fusion within a single bilateral pedicle screw fixation is still common in clinical practice; the two ways after treatment can achieve satisfactory clinical efficacy, but which way has advantages is still controversial.
OBJECTIVE: To evaluate the efficacy and safety of unilateral and bilateral pedicle screw fixation and single segment lumbar interbody fusion in the repair of lumbar degenerative disease by a meta-analysis system.
METHODS: According to the Cochrane Collaboration search strategy, we searched MEDLINE, PubMed, EMBASE, CBMdisc, CNKI, VIP and WanFang Data. Randomized controlled trials concerned unilateral and bilateral pedicle screw fixation and single segment lumbar interbody fusion in the treatment of lumbar degenerative diseases. By two reviewers, in strict accordance with inclusion and exclusion criteria, literatures were screened, data were extracted, and the methodology quality of included trials was critically assessed. RevMan5.1 software was used for meta-analysis.
RESULTS AND CONCLUSION: Six randomized controlled trials involving 507 patients were included. The results of meta-analysis showed that fixed unilateral and bilateral pedicle screw between single lumbar fusion and surgery in the treatment of lumbar degenerative diseases, significant differences were detected in surgical time [WMD=-40.29, 95% CI (-43.79, -36.79)], intraoperative blood loss [WMD= -74.13, 95% CI (-86.13, -62.13)], length of hospital stay [WMD=-1.04, 95% CI (-1.30, -0.79)], final follow-up Visual Analogue Scale score [WMD=0.33, 95% CI (0.24, 0.42)], final follow-up Oswestry dysfunction index [WMD=-1.07, 95% CI (-1.57, -0.56)]; unilateral side was better than bilateral side (P < 0.000 1). There was no significant difference in complication rate [RR=0.54, 95% CI (0.25, 1.17)] and fusion rate [RR=0.53, 95% CI (0.22, 1.28)] (P=0.12 and P=0.16). These results suggested that unilateral and bilateral pedicle screw fixation and single lumbar fusion in the treatment of lumbar degenerative disease has achieved satisfactory results. Unilateral pedicle screw fixation can reduce operation time, intraoperative blood loss and length of stay. Visual Analogue Scale score and Oswestry dysfunction index improved significantly in a short period after treatment.