Chinese Journal of Tissue Engineering Research ›› 2016, Vol. 20 ›› Issue (7): 1044-1050.doi: 10.3969/j.issn.2095-4344.2016.07.019

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Peripheral nerve repair: theory and technology application

He Xin-ze1, Wang Wei2, Hu Tie-min3, Ma Jian-jun4, Yu Chang-yu1, Gao Yun-feng1, Cheng Xing-long4, Wang Pei1   

  1. 1Department of Hand and Foot Surgery, 3Department of Neurosurgery, Affiliated Hospital of Chengde Medical University, Chengde 067000, Hebei Province, China; 2Department of Hand and Foot Surgery, First Hospital of Qinhuangdao, Qinhuangdao 066308, Hebei Province, China; 4Graduate School of Chengde Medical University, Chengde 067000, Hebei Province, China
  • Received:2015-12-07 Online:2016-02-12 Published:2016-02-12
  • Contact: Wang Pei, Master, Professor, Master’s supervisor, Department of Hand and Foot Surgery, Affiliated Hospital of Chengde Medical University, Chengde 067000, Hebei. Province, China
  • About author:He Xin-ze, Studying for master’s degree, Attending physician, Department of Hand and Foot Surgery, Affiliated Hospital of Chengde Medical University, Chengde 067000, Hebei Province, China
  • Supported by:

    the Mandatory Project of Hebei Provincial Health Department, No. 20130027; the Mandatory Project of Hebei Provincial Science and Technology Department, No. 142777105D; a grant from Chengde Science and Technology Department, No. 20123128

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Abstract:

BACKGROUND: Recovery of motor and sensory function from peripheral nerve injury is relatively slow and incomplete. It is a difficult problem for orthopedic surgeons that mainly leads to the decline in the quality of life in patients.
OBJECTIVE: To conclude the methods and corresponding outcomes in peripheral nerve regeneration by analyzing the new treatment means for peripheral nerve injury.
METHODS: PubMed, Wanfang, CNKI databases were retrieved for relevant articles using key words of “nerve injury, regeneration”, and then retrieval data were sorted and analyzed.
RESULTS AND CONCLUSION: In recent years, in-depth studies on peripheral nerve repair have been made in the following aspects: surgical mode, drug, cytokine, gene transfer and biomaterials as well as traditional Chinese medicine. If the detect size is four times longer than the diameter of nerves, the nerve regeneration chamber can achieve good outcomes. The methods of restoring nerve continuity following nerve injury are developed from surgical anastomosis to photochemohistological method, thermal laser welding, plastic repair and other emerging technologies. Studies have found that plasminogen activator, nerve growth factor, neurotrophic factor, recombinant erythropoietin, human tissue kallikrein, B vitamins and their derivatives, herbal preparations, immunosuppressive agents all can promote nerve regeneration.