Tissue-engineered cartilage for repair of sports-induced cartilage injury

doi:10.3969/j.issn.2095-4344.2016.07.018

Abstract

Abstract:

BACKGROUND: Sports-induced cartilage injury is very common; due to the poor self-healing capacity of the cartilage, cartilage repair has always been a difficult problem.
OBJECTIVE: To review the features of different seed cells in tissue-engineered cartilage construction and to explore the application of tissue-engineered cartilage construction in the repair of sports-induced cartilage injury in vitro.
METHODS: We searched PubMed database, Wanfang database and CNKI database for articles related to tissue-engineered cartilage repair of sports-induced cartilage injuries, as well as stem cells and scaffold materials used in tissue-engineered cartilage construction. Totally 190 articles were retrieved, and finally 47 articles were included in result analysis after repetitive studies were excluded.
RESULTS AND CONCLUSION: Bone marrow mesenchymal stem cells under different conditions can differentiate into chondrocytes, and have better potential of chondrogenic differentiation compared with adipose-derived mesenchymal stem cells and umbilical cord-derived mesenchymal stem cells. But, their safety still needs to be further studied. Good scaffolds cannot only induce stem cell differentiation, but also be the key to cartilage construction. Composite materials are the future direction of the scaffold research.

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

Wang Da-peng, Zhang Lan, Zhao Na. Tissue-engineered cartilage for repair of sports-induced cartilage injury[J]. Chinese Journal of Tissue Engineering Research, 2016, 20(7): 1037-1043.

Figures/Tables 1

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