Effects of immediate loadings with different forces on immediate implant-bone ossification

doi:10.3969/j.issn.2095-4344.2013.50.011

Abstract

Abstract:

BACKGROUND: Animal studies showed that functional early load or immediate load on immediate implant did not affect the prognosis of implant.
OBJECTIVE: To analyze the effect of immediate loading with different forces on the binding surface of immediate implant bone ossification.
METHODS: Six adult healthy male dogs were selected. All teeth (three premolars) between cuspid teeth of lower mandible and the first molar were pulled out. One implant (OSSTEM GSII) was immediately implanted, totally 36 implants. The vertical immediate loading by device was used on the implants at 24 hours after implantation. Grouped by the loading force values: 0, 10, 20 N on the left three implants of each dog from front to back, 30, 40, 50 N on the contralateral three implants of each dog, at a frequency of 1 Hz for 10 minutes every day. The implant stability quotient (ISQ) was tested using resonance frequency measurement instrument (OSSTELL) at 0 day, 4, 8, and 12 weeks.
RESULTS AND CONCLUSION: With increased load forces, serum osteocalcin expression increased, and peaked on 20 N, but decreased in 30 N group, and lowest in 50 N group. At 4 weeks after immediate implantation, the ISQ values were slightly less than pre-implantation in each group, especially the 50 N group. At 8 weeks after immediate implantation, ISQ values were increased in each group to different degrees. The increased degree of the 20 N group was maximal. At 12 weeks, a peak value was detected in each experimental group. The implants could bind to bone tissues to different degrees. The range of implant-bone interface formation was positively associated with time. Results indicated that the small force cannot impact implant-bone ossification, but promotes it in a manner, but large force value (≥ 20 N) will affect the stability of the implant-bone ossification.

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

全文链接：

Key words: dental implants, immediate dental implant loading, osteocalcin

CLC Number:

R318

Wu Dan, Hu Na, Li Su-ling, Wang Lu . Effects of immediate loadings with different forces on immediate implant-bone ossification[J]. Chinese Journal of Tissue Engineering Research, doi: 10.3969/j.issn.2095-4344.2013.50.011.

Figures/Tables 2

References

[1] Branemark PI,Breine U,Adell R,et al.Intraosseous anchorage of dental prosthesis. Experimental studies. Plast Reconstr Surg.l969;3:81-100.

[2] Jayme SJ, de Oliveira RR, Muglia VA,et al. The effects of different loading times on the bone response around dental implants: a histomorphometric study in dogs. Oral Maxillofacial Implants.2010;25(3):473-491.

[3] Blanco J,Liñares A,Pérez J,et al. Ridge alterations following flapless immediate implant placement with or without immediate loading. Part II: a histometric study in the Beagle dog. Clin Periodontal.2011;38(8):762-770.

[4] Moon SY, Kim SG, Lim SC. Histological and histomorphometric evaluation of early and immediately loaded implants in the dog mandible. Biomed Mater Res A.2008; 86(4):112-117.

[5] Babbush CA, Kutsko G T, Brokloff, et al. The all-on-four immediate function treatment concept with Nobel Active implants: a retrospective study. Oral Implant.2011;37(4): 431-445.

[6] Tealdo T, Bevilacqua M, Menini M.Immediate versus delayed loading of dental implants in edentulous maxillae: a 36-month prospective study. Prosthodontics.2011; 24(4):1294-1302.

[7] Ravindran DM, Sudhakar U, Ramakrishnan T, et al. The efficacy of flapless implant surgery on soft-tissue profile comparing immediate loading implants to delayed loading implants: A comparative clinical study. Indian Soc Periodontal. 2010;14(4):245-512.

[8] 吴丹,王璐,徐凌,等.即刻种植即刻加载对Beagle犬骨结合界面形成的影响[J].第三军医大学学报,2012,12(30):1197-1201.

[9] 张欣珂,郑小波.犬股骨骨折髓内针内固定和相关因子的变化研究[D].西南大学，2009

[10] 周庆梅,孙健,李亚莉,等.生长因子缓释系统复合纳米支架材料修复犬下颌骨缺损[J].中国组织工程研究,2013,21(17): 3816- 3822.

[11] 崔玉明,冯守诚,王冰封.兔桡骨骨折和骨缺损修复过程中血清骨钙素含量的动态变化[J]兰州医学院学报,1996,22(2):55-58．

[12] Akech J,Wixted JJ,Bedard K,et al.Runx2 association with progression of prostate cancer in patients:mechanisms mediating bone osteolysis and osteoblastic metastatic lesions. Oncogene.2010;29(6):811-821.

[13] 庄龙飞,张志勇,赖红昌.ITI种植体早期负重与传统负重稳定性的比较[J].上海口腔医学,2007,16(3):1276-1281.

[14] 鲍琰,肖立群,施斌,等.Straumann种植体骨愈合期稳定性变化的临床动态监测[J].口腔医学研究,2009,25(6):1321-1326

[15] 许尧祥,李亚莉,陈立强,等.壳聚糖微球/纳米羟基磷灰石/聚乳酸-羟基乙酸复合支架制备及其蛋白缓释效果:与单纯纳米羟基磷灰石/聚乳酸-羟基乙酸支架、壳聚糖微球的比较[J].中国组织工程研究与临床复,2010,14(3):452-456.

[16] Worthington P.Injury to the inferior alveolar nerve during implant placement: A formula for protection of the patient and clinician Oral Maxillofacial Implants.2004;19(5):731-734.

[17] Becker W. Immediate implant placement:Treatment planning and surgical steps for successful outcomes. Br Dent. 2006; 201(4):199-205.

[18] Mara CS, Sartori AR, Duarte AS, et al. Periosteum as a source of mesenchymal stem cells:the effects of TGF-beta3 on chondrogenesis.Clinics(Sao Paulo).2011;66(3):487-857.

[19] 秋霞,罗南萍,王瑞山.IL-6及骨代谢生化指标对骨吸收和骨形成的影响[J].放射免疫学杂志,2003,16(l):33.

[20] Degidi M,Perrotti V,Piattelli A.Immediately loaded titanium implants with a porous anodized surface with at least 36 months of follow-up.Clin Implant Dent Relat Res. 2006;8(4): 169-177.

[21] Bischof M, Nedir R, Szmukler-Moncler S, et al. Implant stability measurement of delayed and immediately loaded implants during healing.Clini Oral Implants Res. 2004;15(5): 529-539.

[22] Bessa PC,Casal M,Reis RL,et al.Bone morphogenetic proteins in tissue engineering: the road from the laboratory to the clinic, part I (basic concepts) .Tissue Eng Regen Med. 2008;2(1):1-13.

[23] Zheng Y, Wu G, Zhao J, et al. rhBMP2/7Heterodimer: An Osteoblasto-genesis Inducer of Not Higher Potency but Lower Effective Concentration Compared with rhBMP2 and rhBMP7 Homodimers.Tissue Eng Part A.2010;16(3):879-887.