Allograft cancellous bone combined with autologous red marrow for treatment of periarticular fractures

doi:10.3969/j.issn.2095-4344.2013.48.020

Abstract

Abstract:

BACKGROUND: Bone defects often occur after the reduction of periarticuar fractures, and bone grafting is required to fill bone defects, thereby to make the early support of articular surface and prevent the collapse and shift of the articular surface. Allograft cancellous bone is the transplant material for the treatment of bone defects, but its osteogenesis ability is poor. Autologous red marrow has osteogenesis ability. Therapeutic efficiency of allograft cancellous bone combined with autologous red marrow for periarticular fractures is still yet to be assessed.
OBJECTIVE: To study clinical effect of locking plate fixation and allograft cancellous bone combined with autologous red marrow in the treatment of periarticular fractures.
METHODS: Forty-three cases of periarticular fractures were incorporated into the Orthopaedics Department of the Third Hospital of Hebei Medical University. After cutting the articular surface anatomically, composite particles of the red marrow and allograft cancellous bone were implanted into bone defects, and then, an anatomic locking plate was used. Medial lateral or bilateral locking plate was used for tibial plateau fractures. Dorsal or volar locking plate was used for distal radius fractures, and distal tibial medial or lateral locking plate was used for distal tibial fractures.
RESULTS AND CONCLUSION: Forty-three patients were followed up for 12 months to 6 years, an average of 4.3 years. X-ray films and CT scans review showed that 43 patients’ collapse fracture all reached bony union. Fresh fracture healing time was 2-6 months, an average of 4 months; the healing time for old fracture was 3- 7 months, an average of 5.5 months. After bone grafting, 43 patients all had no significant immune rejection, two cases showed more wound exudates, and the wound was healed by dressing after 2 weeks. One case had wound infection, the wound was healed after 4 weeks of draining and dressing, and the infection had no recurrence following up for 4 years and 1 month. Forty patients were satisfied with bone grafting, accounting for 93%, and three cases dissatisfied, accounting for 7%, based on Mankin and Komender’s standard assessment. The results confirmed that allograft cancellous bone combined with autologous red marrow transplantation can play a supporting role in treating periarticular fractures to prevent the collapse of the articular surface and fracture displacement, and to provide reconstruction materials for periarticular defects. Its long-term goal is fracture healing.

Key words: bone marrow transplantation, biocompatible materials, bones of lower extremity, graft rejection, tibial fractures

CLC Number:

R318

Kong Zhi-gang, Chen Yong-bao, Sun Lei. Allograft cancellous bone combined with autologous red marrow for treatment of periarticular fractures[J]. Chinese Journal of Tissue Engineering Research, 2013, 17(48): 8419-8428.

Figures/Tables 2

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