Abstract:

BACKGROUND: With the development of new renal injury markers as well as the expression and mechanism in different renal diseases, an important progress has achieved in the protection of renal disease.
OBJECTIVE: To summarize the research progress of renal injury markers.
METHODS: The PubMed database was searched using the computer for articles published from January 2006 to October 2011 using the key words of “renal injury, markers” in English. Simultaneously, China Journal Full-text database were retrieved for articles published from January 2006 to October 2011 using the key words of “renal injury, markers” in Chinese. Besides, Conference Proceedings of English and Chinese were retrieved by hand. Finally, 50 articles were included according to the inclusion criteria.
RESULTS AND CONCLUSION: The prediction and expression of the renal injury markers in different renal disease is distinct. According to time, the renal injury markers can be divided into acute and chronic kidney damage; according to the structure and function, the markers can be divided into glomerular, tubular and glomerular filtration rate; according to the source of specimen, the markers can be divided into blood, urine and tissue biopsy. These markers can not only early detect kidney disease, assess acute kidney injury and can determine the outcome of chronic renal injury. The diversification of renal injury markers is earlier than that of serum creatinine, and the renal injury markers have high sensitivity and specificity, but the screening and clinical application of renal injury markers needs further study on the changes in different individuals, different phase and different comorbidities or complications of kidney damage, and establish the early warning platform in order to achieve the purpose of early diagnosis and treatment of renal injury.