Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (53): 10037-10042.doi: 10.3969/j.issn.2095-4344.2012.53.030

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Effect of multi-drug resistance gene-1 C3435T genetic polymorphism on the concentration of cyclosporine A pharmacokinetics: A Meta-analysis

Li Hai-ju1, 2, Ping Wei-wei3, Song Li-hua1, Guo Chun-hua1, Zheng Wang-qiao1   

  1. 1Department of Pharmacy, 3Department of Preventive Medicine, Changzhi Medical College, Changzhi 046000, Shanxi Province, China
    2Department of Pharmacy, the Affiliated Heping Hospital of Changzhi Medical College, Changzhi 046000, Shanxi Province, China
  • Received:2012-04-05 Revised:2012-04-18 Online:2012-12-30 Published:2012-12-30
  • Contact: Song Li-hua, Master, Professor, Department of Pharmacy, Changzhi Medical College, Changzhi 046000, Shanxi Province, China slh10282001@ yahoo.com.cn
  • About author:Li Hai-ju★, Master, Lecturer, Department of Pharmacy, Changzhi Medical College, Changzhi 046000, Shanxi Province, China; Department of Pharmacy, the Affiliated Heping Hospital of Changzhi Medical College, Changzhi 046000, Shanxi Province, China li_haiju@126.com

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Abstract:

BACKGROUND: Multi-drug resistance gene-1 C3435T genetic polymorphism can influence the function and expression of P-glycoprotein, thus affecting the blood concentration of cyclosporine A, and lead to individual differences. The current studies of the influence of multi-drug resistance gene-1 C3435T genetic polymorphism on the concentration of cyclosporin A pharmacokinetics are inconsistent.
OBJECTIVE: To evaluate the effect of multi-drug resistance gene-1 C3435T genetic polymorphism on the concentration of cyclosporine A pharmacokinetics according to the domestic studies.
METHODS: Case-control studies and cohort studies were collected by searching Cochrane library, Medline database, PubMed database, CNKI database and Wanfang database and supplemented by literature retrospective method from building to 2011-12-31. All the relevant studies were identified and the quality of the included studies was assessed. The RevMan 5.1 software was used for Meta-analysis.
RESULTS AND CONCLUSION: Nine studies with 893 patients were included. The results of Meta-analysis showed that the dose-adjusted c0 level of cyclosporine A of multi-drug resistance gene-1 3435CC genotype was lower than of the CT genotype (P=0.007) and TT genotype (P=0.000 6). The subgroup analysis found that the dose-adjusted c0 level of multi-drug resistance gene-1 3435CC genotype was lower than that of CT genotype (P < 0.000 01) and TT genotype (P=0.000 3) in the patients after renal transplantation. The dose-adjusted c0 level of multi-drug resistance gene-1 3435CC genotype was lower than that of TT genotype (P=0.004) in the patients with hematological diseases. The dose-adjusted c2 level of the multi-drug resistance gene-1 3435CC genotype was lower than that of the TT genotype (P=0.005). The multi-drug resistance gene-1 C3435T genetic polymorphism can influence the blood concentration of cyclosporine A, and the blood concentration of multi-drug resistance gene-1 3435CC genotype was lower than that of TT genotype. High quality and large scale prospective trials are required to study the influence of multi-drug resistance gene-1 C3435T genetic polymorphism on cyclosporine A pharmacokinetics.

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